If ATP consumption in the brain is reduced in such diseases, the UA precursor Hx should also be low. In line with that, a recent meta-analysis found that a number of metabolomic studies of PD patients identified decreases of compounds either related to energy production or purine-related pathways (Havelund et al., 2017).

In this review, we mainly focus on mutations in mitochondrial and nuclear genes encoding ATP synthase subunits and factors important for their association to human diseases. Moreover, we describe the contribution of this enzyme to the pathogenic mechanisms of cardiovascular, neurodegenerative diseases and neurodevelopmental disorders.

Hypophosphatemia is an electrolyte disorder in which there is a low level of phosphate in the blood. [1] . Symptoms may include weakness, trouble breathing, and loss of appetite. [1] . Complications may include seizures, coma, rhabdomyolysis, or softening of the bones. [1]

2019年2月19日 · Some disorders of those organs may reflect dysfunction in energy-consumption/production, and the observed beneficial effects related to reinforcement of ATP re-synthesis due to increased hypoxanthine levels in the blood and tissues.

2010年6月1日 · Mitochondria consume the greatest amount (some 85–90%) of oxygen in cells to allow oxidative phosphorylation (OXPHOS), which is the primary metabolic pathway for ATP production. Therefore hypoxia will hamper this metabolic pathway, and if the oxygen level is very low, insufficient ATP availability might result in cell death [15] .

2023年9月1日 · Regions of insufficient ATP concentrations are created which requires targeted intracellular energy trafficking. These regions of low intracellular ATP could be equilibrated via the formation and transport of a glycolytic metabolon or via the redistribution of …

2021年4月8日 · In this review, we focus on human diseases caused by altered expressions of ATP synthase genes of both mitochondrial and nuclear origin. Moreover, we describe the contribution of ATP synthase to the pathophysiological mechanisms of other human diseases such as cardiovascular, neurodegenerative diseases or neurocognitive disorders.

Results: We found that permanent oxygen deprivation attenuated cellular ATP levels in these cells, diminishing mitochondrial ATP production but stimulating glycolytic ATP production. At the same time, permanent hypoxia did not affect MMSCs' viability, stimulated their proliferation and reduced their capacity to differentiate.

2022年9月9日 · For patients with heart failure, myocardial ATP level can be reduced to one-half of that observed in healthy controls. This marked reduction (from ≈8 mM in healthy controls to as low as 3–4 mM in heart failure) has been suggested to contribute to impaired myocardial contraction and to the decreased pump function characteristic of heart failure.

2010年8月31日 · Intracellular ATP levels are generally in the low millimolar range, but ATP at a level within this range was shown to inhibit proteasome peptidase activities in vitro. Here, we report new...