2020年11月12日 · Lox-1 (lectin-like oxLDL [oxidized low-density lipoprotein] receptor 1) is a transmembrane protein expressed in endothelial cells, platelets, macrophages, smooth muscle cells, and cardiomyocytes. Activation of Lox-1 by oxLDL is implicated in the progression of atherosclerosis, myocardial fibrosis, and endothelial dysfunction.

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene. [5] [6] LOX-1 is the main receptor for oxidized LDL on endothelial cells, macrophages, smooth muscle cells, [7] and other cell types. [8]

The LOX-1 gene has a NF-κB binding site at its 5’ flanking region, and therefore ox-LDL increases the expression of LOX-1 through NF-κB, leading to a vicious cycle of proinflammatory signaling .

The splicing variant LOX IN dimerizes with the native form of LOX-1 and protects cells from damage by oxidized LDL. In the developing field of regenerating medicine, LOX-1 is a potential target for therapeutic intervention.

2021年10月5日 · Here, we clarified the exact role of autophagy modulated by the scavenger receptor lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in esophageal cancer (EC). A comprehensive...

OxLDL激活LOX-1会引起内皮细胞改变，其特征是通过增加活性氧来激活核因子-κB，随后诱导粘附分子和内皮细胞凋亡。 在体外，LOX-1的表达是由许多炎性细胞因子，氧化应激，血液动力学刺激和OxLDL诱导的。 在体内，该表达在促动脉粥样硬化环境中（包括高血压，高脂血症和糖尿病）增强，并且实际上在动脉粥样硬化和肾小球硬化病变中积累。 LOX-1结合与动脉粥样硬化发病机制有关的多种配体。 除OxLDL外，LOX-1还可以识别凋亡/老化的细胞，活化的血小板和细 …

2015年11月18日 · We used structure-based drug design (SBDD) techniques for finding inhibitors of LOX-1 that block the hydrophobic tunnel and prevent ox-LDL/LOX-1 interactions. Towards this goal, we explored a...

2021年5月7日 · The lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1), a scavenger receptor that promotes endothelial dysfunction by inducing pro-atherogenic signalling and plaque formation via the endothelial uptake of oxidized LDL (oxLDL) and electronegative LDL, contributes to the initiation, progression, and destabilization of ...

2021年12月3日 · 氧化性低密度脂蛋白受体-1 （ lox-1 ）是胞外段含有典型的 c 型凝集素样结构的模式识别受体，在动脉粥样硬化、高血脂和糖尿病等代谢性疾病中表达上调，而这些代谢性疾病都与肿瘤发生高度相关。

2020年6月10日 · Here we describe the identification and characterization of BI-0115, a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. Identified by a high throughput screening...