Multiple extrathymic precursors contribute to T-cell …
2010年2月11日 · The most immature T-cell progenitors in the thymus are lineage negative (lin −), CD44 +, CD25 −, Sca-1 high, CD117 (c-kit) high (LSK), and CD127 −/lo (IL-7Rα) early T …
造血干细胞表面标志物 - 知乎 - 知乎专栏
已经定义了两种类型的造血干细胞：能够终生保持自我更新和多谱系分化潜能的长期再生细胞 (LTRC)；来源于LTRC的短期再生细胞 (STRC)，虽然它们保持了多能性，但它们表现出更有 …
JCI - Zeb1 modulates hematopoietic stem cell fates required for ...
2020年10月27日 · LSK CD135 hi CD127 hi lympho-myeloid MPPs (LMPPs CD127 +, nonconventional LMPP) rapidly and efficiently generate T and innate lymphoid cells (35) …
Lin-Sca1+Kit- bone marrow cells contain early lymphoid …
Here, we show that LSK - cells contain early lymphoid committed precursors with both T and B cell potential that are functionally and phenotypically distinct from CLPs. In addition, a …
Identification of immune-activated hematopoietic stem cells
2018年7月24日 · Acute and extended immune stimulation provokes conventional HSC markers. a Representative FACS plots, showing the staining of the Lineage − cKit + Sca1 + (LSK) …
Loss of Zeb1 results in a reduction of lymphoid progenitors in BM …
Interestingly, we found a significant reduction in the proportion of T cell lineage-primed LMPP CD127 + , but not conventional LMPP, which showed a statistically insignificant trend toward ...
从干细胞到早期祖细胞：光谱流式对小鼠造血系统的深度分析
2022年2月10日 · 来自辛辛那提儿童医院医学中心的Damien Reynaud博士结合多种经典的造血系统表型分析方案，开发了可同时分析小鼠HSC及HSPC亚群的14色全光谱流式分析方案，旨在 …
Essential role of Dhx16-mediated ribosome assembly in ... - Nature
2024年9月27日 · Our findings reveal the critical role of Dhx16 in HSC homeostasis through the regulation of alternative splicing and ribosome assembly, providing insights into the molecular …
CD127-Directed Immunotherapy with Lusvertikimab Outperforms …
2024年11月5日 · Immunotherapy targeting IL-7Rα (CD127) employing research-grade antibodies has shown promising results in preclinical models of BCP-ALL, including BCR::ABL1 + patient …
深度剖析 | NovoCyte Quanteon流式细胞仪对小鼠造血干细胞和祖 …
2022年11月3日 · 然后在Sca-1和c-Kit低表达的细胞群中进一步分析CD135和CD127以区分CLP（LSlowKlow，CD135 + CD127 +）。 14色HSPCs方案基于安捷伦 NovoCyte Quanteon …