2024年12月25日 · LTB4R2 (Leukotriene B4 Receptor 2) is a Protein Coding gene. Diseases associated with LTB4R2 include Psoriasis 5 and Persistent Mild Asthma. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

Leukotriene B4 receptor 2, also known as BLT2, BLT2 receptor, and BLTR2, is an Integral membrane protein that is encoded by the LTB4R2 gene in humans and the Ltbr2 gene in mice. [5][6][7]

预计可启用 G 蛋白偶联肽受体活性和白三烯 B4 受体活性。 预计参与炎症反应和神经肽信号通路。 预计在角质形成细胞迁移和信号转导的上游或内部起作用。 位于核质和质膜中。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in inflammatory response and neuropeptide signaling pathway.

2017年10月1日 · Leukotriene B 4 (LTB 4), a lipid mediator produced from arachidonic acid, is a chemoattractant for inflammatory leukocytes. We identified two receptors for LTB 4, the high-affinity receptor BLT1 and the low-affinity receptor BLT2.

2023年6月2日 · 12-HHTrE是一种来源不明的17碳多不饱和脂肪酸，它是白三烯B4受体2（LTB4R2）的配体，涉及多种恶性肿瘤，但迄今为止均与HCC无关。 本实验结果表明，aHSC SCD2控制LTB4R2及其亲和力最高的氧脂配体12-HHTrE的表达，并且LTB4R2激活可能抑制了Scd2f/f CC小鼠的肿瘤发生。 4.

2023年5月8日 · Tumor suppression is associated with reduced leukotriene B4 receptor 2 (LTB4R2) and its high affinity oxylipin ligand, 12-hydroxyheptadecatrienoic acid (12-HHTrE). Genetic or pharmacological...

2025年2月8日 · Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation. Prognostic and immunological value of LTB4R in pan-cancer. The critical roles of BLT2 on the functions of bronchial epithelial cells.

2024年1月1日 · Transcriptomic analysis of Ltb4r2−/− and WT macrophages suggested a role for BLT2 in macrophage migration, and studies in vitro confirmed that whereas BLT2 does not mediate macrophage polarization, it is required for chemotactic function, possibly mediated by downstream genes Ccl5 and Lgals3.

2025年2月8日 · findings suggest that a leukotriene B4 receptor-2-linked cascade plays a pivotal role in LPS/TLR4 signaling for IL-13 synthesis in mast cells, thereby potentially exacerbating allergic response. BLT2 expression in mast cells is essential for the production of VEGF in OVA-induced allergic asthma.

2022年3月1日 · 运用生物信息学分析白三烯B4受体（LTB4R）在急性髓系白血病（AML）患者中的表达模式、预后价值和潜在生物学功能。 从癌症基因组图谱（TCGA）数据库和美国国立生物技术信息中心（NCBI）公共基因芯片数据平台（GEO）下载mRNA基因芯片数据集和临床基线资料数据集，利用R studio进行表达分析、生存分析、Cox风险回归分析、相关性分析研究LTB4R的表达模式和预后价值。 利用UALCAN平台研究LTB4R表达水平与临床特征的关联。 利 …