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Plaques are palpable lesions > 10 mm in diameter that are elevated or depressed compared to the skin surface. Plaques may be flat topped or rounded. Lesions of psoriasis and granuloma annulare commonly form plaques. Psoriasis typically manifests as plaques covered with thick, silvery, shiny scales.

2024年6月26日 · Acute plaque rupture with luminal thrombosis is the major cause of myocardial infarction and sudden death. Because of the histological diversity of atherosclerotic lesions, 1 it is essential to simplify plaques into unstable and stable plaques to accurately understand and provide better clinical context for this devastating disease. This review ...

Stable atherosclerotic plaques are characterized by a thick, extracellular matrix-rich fibrous cap populated by protective ACTA2 + myofibroblast (MF)-like cells, assumed to be almost exclusively derived from smooth muscle cells (SMCs).

2019年11月25日 · We thus successfully used 19 F MRI for the noninvasive quantification of PFC in atherosclerotic plaque in mice on a clinical scanner, demonstrating the feasibility of detecting very small...

It is becoming more recognized now that biomarkers based on MRI models of plaque significance, such as mechanical forces defined as vulnerable plaque wall stress or low shear stress, may be considered during the early prediction of possible acute vascular events [82,103].

2017年5月8日 · Local treatment of vulnerable plaques by percutaneous coronary intervention and systemic treatment with anti-inflammatory and low-density lipoprotein–lowering drugs are currently being investigated in large randomized clinical trials to assess their therapeutic potential for reducing adverse coronary events.

2017年12月15日 · Herein, we report a coumarin-quinoline (CQ) conjugate-based turn-on near-infrared (NIR) fluorescence probe for specific detection of β-amyloid (Aβ) aggregates. CQ probe is highly sensitive and exhibits ~100-fold fluorescence enhancement in vitro upon binding Aβ aggregates with enhanced quantum yield.

CT-derived vulnerable plaque characteristics are independently associated with hyperemic flow indices as assessed with FFR and iFRa, but not with non-hyperemic indices such as iFR and Pd/Pa. These findings suggest that the effects of hyperemia on pressure-derived indices might depend not only on hem …

2020年8月14日 · The present state-of-the-art document aims to present and critically appraise the latest evidence, developments, and future perspectives in detection, prevention, and treatment of 'high-risk' plaques occurring in 'vulnerable' patients.