The generation of reactive oxygen species (ROS) plays an important role for the maintenance of cellular processes and functions in the body. However, the excessive generation of oxygen radicals under pathological conditions such as acute lung injury (ALI) and its most severe form acute respiratory d …

Reactive oxygen species (ROS), either derived from exogenous sources or overproduced endogenously, can disrupt the body's antioxidant defenses leading to compromised redox homeostasis. The lungs are highly susceptible to ROS-mediated damage.

2021年5月22日 · ROS play a vital role in vascular homeostasis; however, excessive ROS can impair lung function and alter pulmonary vasculature as implicated in COPD. Increased endothelial dysfunction and inflammatory cell infiltration contribute to the severity of the disease.

In this review, we discuss mechanisms of oxidant stress in the lung, the role of oxidants in lung disease pathogenesis and exacerbation. Reactive oxygen species (ROS) are well recognized for playing a dual role as both deleterious and beneficial species.

2025年3月19日 · Hypoxia, inflammatory response and pathogen (bacterial or viral) infection are the three main factors that lead to death in patients with acute lung injury (ALI). Among them, hypoxia activates the expression of HIF-1α, further exacerbating the production of ROS and inflammatory response.

Excessive ROS generated by the injured endothelium/epithelium as well as recruited leukocytes plays a major role in ARDS progression and lung damage. Oxidative stress can be a cause of the endothelial and epithelial barrier dysfunctions resulting in massive neutrophil penetration across the barriers followed by secretion of cytotoxic agents ...

ROS-1 rearrangement is found in 0.9–2.6% of non-small-cell lung cancers (NSCLCs), mostly lung adenocarcinomas, with a significantly higher rate of women, non-smokers, and a tendency to a younger age.

OS increases the production of reactive oxygen species (ROS), including superoxide anions (O 2−), hydroxyl radicals (OH) and hydrogen peroxide (H 2 O 2), by the transformation of oxygen through enzymatic and non-enzymatic reactions. In this manner, OS reduces endogenous antioxidant defenses in both nucleated and non-nucleated cells.

2005年7月31日 · We have established a protocol for the measurement of intravascular ROS release from isolated buffer-perfused and ventilated rabbit and mouse lungs, combining lung perfusion with the spin probe l-hydroxy-3-carboxy-2,2,5,5 …

2024年1月29日 · External oxidative stimuli and endogenous reactive oxygen species (ROS) play a crucial role in promoting lung carcinogenesis and development. The biological properties of higher ROS levels in tumor cells than in normal cells make them more sensitive and vulnerable to …