Lupeol is a pentacyclic triterpenoid that is lupane in which the hydrogen at the 3beta position is substituted by a hydroxy group. It occurs in the skin of lupin seeds, as well as in the latex of fig trees and of rubber plants. It is also found in many edible fruits and vegetables. It has a role as an anti-inflammatory drug and a plant metabolite.

These studies also provide insight into the mechanism of action of Lupeol and suggest that it is a multi-target agent with immense anti-inflammatory potential targeting key molecular pathways which involve nuclear factor kappa B (NFκB), cFLIP, Fas, Kras, phosphatidylinositol-3-kinase (PI3K)/Akt and Wnt/β-catenin in a variety of cells.

羽扇豆醇(lupeol)是一种三萜烯，分子量为426.72。 羽扇豆醇存在于羽扇豆种子的表皮中、无花果树和橡胶植物的胶乳中，还广泛存在于草莓、芒果、葡萄、橄榄等水果之中 。

2024年11月1日 · Lupeol, a triterpene derived from various plants, has emerged as a potent dietary supplement with extensive therapeutic potential. This review offers a comprehensive examination of lupeol’s applications across diverse health conditions.

2009年10月1日 · Anticancer, antiprotozoal, chemopreventive and anti-inflammatory properties, plus the mechanisms of action of lupeol are emphasized. Some insights are provided regarding lupeol as a lead...

2009年11月28日 · It is noteworthy that Lupeol at its effective therapeutic doses exhibit no toxicity to normal cells and tissues. This mini review provides detailed account of preclinical studies conducted to determine the utility of Lupeol as a therapeutic and chemopreventive agent for the treatment of inflammation and cancer.

2021年12月16日 · We showed that administration of lupeol (50 mg ·kg -1 · d -1, i.g., for 4 weeks) prevented the morphological changes and cardiac dysfunction and remodeling in TAC mice, and treatment with...

2004年5月3日 · We found that Lupeol treatment to mouse skin resulted in the inhibition of TPA-induced (i) activation of PI3K, (ii) phosphorylation of Akt at Thr 308, (iii) activation of NF- κ B and IKK α, and...

2009年11月28日 · This study showed that pretreatment with Lupeol (1 mg/animal) for 7 days prior to B(a)P administration significantly decreased B(a)P-induced clastogenicity and caused an increase in mitotic index [52].

Lupeol belongs to pentacyclic lupane-type triterpenes and exhibits in edible vegetables, fruits and many plants. Many researches indicated that lupeol possesses many beneficial pharmacological activities including antioxidant, anti-inflammatory, anti-hyperglycemic, anti …