Forty-five patients suffering from systemic lupus erythematosus were studied in respect of their serologically defined HLA antigens. HLA-B8 antigen was found in 37-8% of patients as compared to 22% of controls.

2013年7月18日 · Together with genetic and molecular epidemiology, they have made it possible to establish and hypothesize the plausible mechanisms of association between HLA genetic variants and the pathophysiology of ADs, e.g., rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes mellitus (T1D), multiple sclerosis (MS), celiac ...

Aim: Human leukocyte antigen (HLA)-DRB1 allele polymorphisms have been reported to be associated with systemic lupus erythematosus (SLE) susceptibility, but the results of these previous studies have been inconsistent.

The primary SLE association signal in the entire MHC region has long been identified to be located at HLA-DRB1 in the MHC class II regions or HLA-DRB1 -associated long-range HLA-gene haplotypes in multiple ancestral populations (Figure 1).

We explored the association between HLA-B and HLA-DRB1 polymorphisms and reviewed clinical characteristics of systemic lupus erythematosus (SLE) in Han population in Yunnan, China. There were 295 patients and 265 healthy control subjects (HCs) enrolled in the study. Clinical data and blood samples were collected from the patients.

2022年9月6日 · New findings support the existence of an antigen presentation-independent mechanism known as the ‘cusp theory’ and the involvement of a newly discovered ‘lupus epitope’ in systemic lupus ...

2024年11月1日 · Genetic variants within HLA-DRB1, HLA-DRB5, HLA-DQA1, HLA-DQB1, IRF7, IRF5, BLK and HLA-DPA1 play a pivotal role in SLE. Functional genes within genomic loci associated with systemic lupus erythematosus (SLE), as identified by genome-wide association studies, exhibit cell-specific characteristics.

Of the genetic elements, the genes of the major histocompatibility complex (MHC) have been most extensively studied for their contribution to human SLE. Population studies reveal that the susceptibility to SLE involves human leucocyte antigen (HLA) class II gene polymorphisms.

2025年3月17日 · For example, the C4A -null allele was associated with a doubled SLE susceptibility than either HLA-B8 or HLA-DR3, 166 where HLA-B8 and HLA-DR3 alleles were known to predispose the risk of SLE via ...

2018年12月5日 · Systemic lupus erythematosus (SLE) is an autoimmune disease under genetic control. Growing evidences support the genetic predisposition of HLA-DRB1 gene polymorphisms to SLE, yet the results are not often reproducible.