CD45 negatively regulates lyn activity by dephosphorylating both ...
1999年8月1日 · Using CD45-deficient clones from the immature B cell line, WEHI-231, we previously demonstrated that CD45 selectively dephosphorylates the Src-family protein …
Lyn Tyrosine Kinase: Immunity - Cell Press
2004年12月2日 · Lyn can be activated by dephosphorylation of the C-terminal regulatory tyrosine by CD45. CD45 is shown within the lipid raft and acting to dephosphorylate Y508 for graphic …
CD45: all is not yet crystal clear - PMC
There is certainly evidence that CD45 acts on Lyn (and presumptively other SFKs) in B cells, mainly from cell lines, 60 – 62 but also recently from primary CD45KO B cells; 63 these data …
CD45 Modulates Phosphorylation of Both Autophosphorylation …
1996年11月29日 · We have studied effects of CD45 on Lyn using CD45-deficient DT40 B cells. Lyn is dominantly expressed among Src family PTKs in DT40 cells. Our results demonstrated …
Modulation of immune cell signalling by the leukocyte common …
2010年3月1日 · In BCR and FcR signalling in B cells and mast cells, CD45 has a positive effect that can be achieved by both activating and inactivating Lyn. CD45 can dephosphorylate the …
CD45 Negatively Regulates Lyn Activity by Dephosphorylating …
1999年8月1日 · A study on the chicken DT40 B cell line showed that CD45 dephosphorylates both the positive and the negative regulatory tyrosine residues of Lyn but the activity of Lyn is …
CD45, CD148, and Lyp/Pep: Critical Phosphatases Regulating Src …
Here, we focus on the role of three phosphatases, CD45, CD148, and LYP/PEP, which are critical regulators of src family kinase activity in hematopoietic cells. We review our current …
Structural Wedge Domain of the Receptor-like Tyrosine Phosphatase CD45 ...
2013年3月15日 · Lyn is required to mediate phenotype of H/H, but not E613R, B cells. (A) Whole-cell lysates of resting B cells from E613R, +/+, and CD45 −/− mice genetically sufficient or …
CD45 modulates phosphorylation of both autophosphorylation …
1996年11月29日 · We report here that both autophosphorylation and C-terminal negative regulatory tyrosines of Lyn were hyperphosphorylated in CD45-deficient DT40 B cells. In this …
Selective Regulation of Lyn Tyrosine Kinase by CD45 in
1995年11月24日 · The results clearly demonstrated that among PTKs examined (Lyn, Lck, and Syk), only Lyn kinase is dysregulated in the absence of CD45 such that without B cell antigen …