Lysozyme (EC 3.2.1.17, muramidase, N-acetylmuramide glycanhydrolase; systematic name peptidoglycan N-acetylmuramoylhydrolase) is an antimicrobial enzyme produced by animals that forms part of the innate immune system. It is a glycoside hydrolase that …

Lysozyme is a small, stable enzyme, making ideal for research into protein structure and function. Brian Matthews at the University of Oregon has performed a remarkable series of experiments, using lysozyme as the laboratory for study.

Jul 27, 2024 · Explore the structure, sources, and diverse applications of lysozyme, including its role in immune response and potential therapeutic uses. Discovered over a century ago, lysozyme remains a molecule of significant scientific interest due to its multifunctional properties.

In physiological conditions, lysozyme is folded into a compact, globular structure with a long cleft in the protein surface. This cleft is the active site involved in binding to the bacterial …

Lysozyme is an enzyme present in both animal and human lacrimal gland secretions (or tears), gastric secretions, nasal mucus, and egg white. It is discovered in 1921 by Sir Alexander Fleming.

Mar 2, 1999 · Explore in 3D: Structure | Sequence Annotations | Electron Density | Validation Report

Jul 11, 2024 · Peptidoglycan is a rigid structure that provides support and protection to bacterial cells. By cleaving these bonds, lysozyme weakens the bacterial cell wall, leading to the rupture and death of the bacterium. Lysozyme is particularly effective against Gram-positive bacteria, which have a relatively thick peptidoglycan layer.

Nov 10, 1997 · Enzymes are thought to use their ordered structures to facilitate catalysis. A corollary of this theory suggests that enzyme residues involved in function are not optimized for stability. We tested this hypothesis by mutating functionally …

Jan 2, 2025 · The paper “structure and dynamics of the active site of hen egg-white lysozyme from atomic resolution neutron crystallography” by Ramos et al. 1 reports two neutron crystallographic structures of the enzyme lysozyme—one of perdeuterated protein and the other deuterium-exchanged—at atomic resolution.

Aug 21, 1996 · The refined structure of human lysozyme labeled by 2',3'-epoxypropyl beta-glycoside derivatives of N,N'-diacetylchitobiose (HL/NAG-NAG-EPO complex) indicated that the interaction mode of the N,N'-diacetylchitobiose moiety in substites B and C in this study was essentially the same as in the case of the complex of human lysozyme with the free ...