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Membranoproliferative glomerulonephritis (MPGN) is a type of glomerulonephritis caused by deposits in the kidney glomerular mesangium and basement membrane (GBM) thickening, [2] activating the complement system and damaging the glomeruli. MPGN accounts for approximately 4% of primary renal causes of nephrotic syndrome in children and 7% in adults.

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Membranoproliferative glomerulonephritis (MPGN) is a disease that affects the glomeruli, or filters, of the kidneys.

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膜增生性 肾小球 肾炎 (MPGN)，是 肾小球肾炎 中最少见的类型之一，一般分为 原发性 和 继发性。 此病曾用名包括 系膜毛细血管性肾小球肾炎 (MCGN)、 系膜 毛细血管增生性肾炎、小叶性肾炎、低 补体 血症 性肾炎等。 本病是一种具有特定病理形态及免疫学表现的综合征。 临床主要表现为肾炎、 肾病 或肾炎肾病同时存在和低补体血症； 组织学 上可见系膜增生， 毛细血管壁 增厚，肾小球呈分叶状，故又称分叶性肾炎。 其病理改变的主要特点是系膜 细胞增生 、毛细血管壁增 …

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膜增生性肾小球肾炎（Membranoproliferative Glomerulonephritis，MPGN）是肾病综合征相对少见的病理类型，也称为系膜毛细血管性肾小球肾炎，典型的病理表现即光镜下系膜中-重度增生，增生的系膜细胞和基质向内皮细胞下插入，形成新的基质成分，与基底膜并行排列，称作「双轨征」，导致毛细血管腔狭窄。 既往将该病理类型分为 I、II、III 型，但后来发现 II 型膜增生性肾炎，其实是由于补体 C3 的代谢异常引起的致密物沉积病（DDD），而 I、III 型分型仍然保留至今， …

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