2025年2月1日 · XGBoost-based M−THAL model differentiates Normocytic-TT, Microcytic-TT, IDA, and controls. Includes thalassemia trait with normal MCV, addressing screening method gaps. …

2018年1月13日 · Inherited haemoglobin disorders, including thalassaemia and sickle-cell disease, are the most common monogenic diseases worldwide. Several clinical forms of α …

2023年10月6日 · β-thalassemia syndromes are a heterogeneous range of anemias and a major source of morbidity, mortality, and substantial financial burden globally. The disease is …

The term ‘thalassaemia’ refers to a group of blood diseases characterised by decreased or absent synthesis of one or more of the normal globin chains. According to the chain whose synthesis …

2011年10月20日 · β-thalassemia is a disease characterized by anemia and is associated with ineffective erythropoiesis and iron dysregulation resulting in iron overload. The peptide …

2005年4月1日 · Here we report the generation of a mouse model carrying the codons 41–42 (−TTCT) β-thalassemia mutation in the intact human β-globin locus. This mutation accounts …

2023年8月8日 · Thalassemias are a heterogeneous grouping of genetic disorders that result from a decreased synthesis of alpha or beta chains of hemoglobin (Hb). Hemoglobin serves as the …

Thalassemia syndromes are recessively inherited hemoglobinopathies in which the reduced or absent synthesis of hemoglobin chains results in chronic anemia of varying severity. 1 With an …

Thalassemia is a heterogeneous group of blood disorders affecting the hemoglobin genes and resulting in ineffective erythropoiesis. The decreased production of hemoglobin results in …

2018年1月13日 · Inherited haemoglobin disorders, including thalassaemia and sickle-cell disease, are the most common monogenic diseases worldwide. Several clinical forms of α …