In this study, we show that OPA1 has a crucial role in macrophage activation. Selective Opa1 deletion in myeloid cells impairs M1-macrophage commitment. Mechanistically, Opa1 deletion leads to TCA cycle metabolite accumulation and defective NF-κB signaling activation.

2022年10月28日 · In this study, we show that OPA1 has a crucial role in macrophage activation. Selective Opa1 deletion in myeloid cells impairs M1-macrophage commitment. Mechanistically, Opa1 deletion leads...

Results: Administration of M1 significantly promoted mitochondrial fusion and attenuated the reduction in optic atrophy 1 (Opa1) expression in diabetic hearts. Importantly, M1 treatment attenuated oxidative stress, improved mitochondrial function and alleviated DCM in diabetic rats.

2023年2月7日 · Enhancing mitochondrial fission and donut formation through Opa1 knockdown or Fis1 overexpression increases mitochondrial secretion and accelerates osteogenesis. We also show that mitochondrial fusion promoter M1, which induces Opa1 expression, impedes osteogenesis, whereas osteoblast-specific Opa1 deletion increases bone mass.

In this study, we show that OPA1 has a crucial role in macrophage activation. Selective Opa1 deletion in myeloid cells impairs M1-macrophage commitment. Mechanistically, Opa1 deletion leads...

In this study, we show that OPA1 has a crucial role in macrophage activation. Selective Opa1 deletion in myeloid cells impairs M1-macrophage commitment. Mechanistically, Opa1 deletion leads to TCA cycle metabolite accumulation and defective NF-κB signaling activation.

2024年1月1日 · It has been shown that M1, a pharmacological mitochondrial fusion promoter, alleviated high glucose-induced oxidative stress and diabetic cardiomyopathy in rats via enhancing OPA1-dependent mitochondrial fusion (Fig. 4 B) [119].

2019年9月19日 · In the present study, M1 decreased the mitochondrial fusion protein OPA1 in the 2D culture of the human iPSC-Foreskin-2 cell line despite a shift towards fusion in iPSC mitochondria (Figure 1(d)). The reason for this is unclear although the M1-induced OPA1 reduction was not observed in the CERA007c6 iPSC line (Supplementary Fig. ).

视神经萎缩 1 (opa1) 是一种线粒体形成蛋白，可控制线粒体融合、嵴生物发生和呼吸；明确的证据表明，这种蛋白质的活性缺乏或功能失调会触发 tca 循环代谢中间体的积累。

2021年12月6日 · Here, we show that the mitochondrial cristae biogenesis protein optic atrophy 1 (Opa1) facilitates cell-autonomous adipocyte browning. In two cohorts of patients with obesity, including weight...