DNA Mismatch Repair Interacts with CAF-1- and ASF1A-H3-H4 ... - PubMed
2016年4月22日 · The first step in replication-coupled nucleosome assembly is CAF-1-dependent histone (H3-H4)2 tetramer deposition, a process that involves ASF1A-H3-H4 complex. In this …
SCI热点 | CAF最强汇总来啦 - 知乎 - 知乎专栏
2023年4月23日 · 广泛报道的亚型包括富含ecm转录本的 肌成纤维细胞 caf(mycaf)；富含炎症反应和生长因子转录本的 炎性caf (icaf)；富含mhc ii转录本的 抗原提呈caf (apcaf)。以及其他亚 …
Cancer cell | 肿瘤相关成纤维细胞的亚型决定了肺癌不同的治疗模 …
近期，在Cancer cell杂志上发表了一篇名为“Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms”的文章，文章中建立了一个CAF生物库，这些CAF来源于非小细 …
Histone acetyltransferase 1 is required for DNA replication fork ...
2020年6月19日 · Histone H3 lysine 56 acetylation has been shown to positively regulate binding of histones to CAF-1 (38). Consistent with this, loss of H3 lysine 56 acetylation and CAF-1 …
In this work we used reconsti-tuted human systems to investigate interactions between MMR and CAF-1- and ASF1A-H3-H4-dependent histone (H3-H4)2 tetramer deposition. We have found …
新型抗肿瘤治疗策略：靶向肿瘤相关成纤维细胞(CAF) - 知乎
这些被激活的成纤维细胞被称为癌症相关成纤维细胞(caf)。 通过产生可溶性因子，如细胞因子、趋化因子以及细胞外基质，CAF可以促进癌细胞生长、抑制肿瘤免疫反应、重塑ECM、影响肿 …
An analysis of CAF-1-interacting proteins reveals dynamic and …
2011年3月25日 · CAF-1 is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork. Depletion of CAF-1 from various cell lines causes replication …
The Role of Histone Modification in DNA Replication-Coupled …
CAF-1 is recruited to the replication fork through direct interaction with PCNA [43,44], and promotes nucleosome assembly through interaction with Asf1. The CAF-1-Asf1 histone …
DNA mismatch repair interacts with CAF-1- and ASF1A-H3-H4 …
We have found that MutSα inhibits CAF-1- and ASF1A-H3-H4-dependent packaging of a DNA mismatch into a tetrasome. This finding supports the idea that MMR occurs before the DNA …
缺氧微环境决定癌症相关成纤维细胞的表型可塑性和空间分 …
最近的单细胞 RNA 测序 (scRNA-seq) 技术证实了多种癌症类型中以前未被认识到的癌症相关成纤维细胞 (CAF) 异质性。 1 在几种 CAF 亚型中，肌纤维母细胞 CAF (myCAF) 和炎症性 CAF …