2017年2月14日 · We hypothesized that a cell therapy using microglia preconditioned by optimal oxygen-glucose deprivation (OGD) is a therapeutic strategy for ischemic stroke because …

The gene expression of M1 and M2 BV2 phenotype markers was assessed using quantitative polymerase chain reaction (qPCR). The localization of M1 and M2 BV2 markers was detected …

旨在阐明 Lobetyolin 对氧糖剥夺/再灌注 (OGD/R) 诱导的 BV2 小胶质细胞损伤的保护机制。 采用化学建模方法建立 OGD/R 模型，模拟洛贝乔林预处理的 BV2 细胞体内脑缺血。

Microglial M1/M2 polarization plays a pivotal role in inflammation and ferroptosis during OGD/R. The BMP6/SMADs signaling pathway is a potential therapeutical target of inflammation and …

2023年7月1日 · In the present study, we co-cultured M2 microglial exosomes and a HT22 cell model of OGD/R injury to elucidate the effects of M2 microglia exosomes on ferroptosis in …

2021年11月9日 · Our results suggest that OGD-preconditioning transfers microglia into the anti-inflammatory M2 phenotype, which yields enrichment of the TGF-β1 protein inside of EVs …

目的探讨trem2调控氧糖剥夺/复氧（ogd/r）模型小鼠小胶质细胞向m2型极化的机制。 方法体外培养N9小胶质细胞系,采用TREM2过表达慢病毒（LV-TREM2）转染N9细胞,空载病毒LV …

2022年5月30日 · In this study, we established an in vitro oxygen/glucose deprivation and re-oxygen/glucose (OGD/R) model to investigate the potential role of M2-Exo in protecting HT22 …

研究表明，外伤性脑损伤后小胶质细胞及其外泌体中miR-124-3p表达上调，不仅抑制神经元的炎症反应，M2型小胶质细胞源性外泌体(M2-exo)还可转移到神经元中促进突触生长 。M2-exo是否 …

2023年10月14日 · To investigate the effect of OGD/R injury on BV2 polarization, we performed immunofluorescence staining of M1 and M2 BV2 phenotype markers. CD16/32 is a commonly …