游富平团队揭示天然免疫信号调控m⁶A修饰的新机制_澎湃号·湃客_ …
2022年2月18日 · 该研究揭示了天然免疫信号调控m6A修饰的新机制，即TBK1同时参与调控METTL3的m6A活性和蛋白质翻译功能，促进机体的一型干扰素应答。 作者专访. Cell Press细胞出版社特别邀请本文通讯作者游富平研究员代表研究团队进行了专访，请他为大家进一步详细解读。 CellPress： N6-methyladenosine（m6A）是高等真核生物中最丰富的mRNA修饰，并被证实调节多种生理和病理过程，但是其在抗病毒免疫中的功能一直存在争议，请问目前争议的焦点主要 …
TBK1-METTL3 axis facilitates antiviral immunity - Cell Press
2022年2月15日 · Chen et al. report that TBK1 promotes METTL3-related translation and m6A modification in a kinase-activity-dependent and -independent manner. This study therefore advances our understanding of how innate signals interplay with METTL3 in …
TBK1-METTL3 axis facilitates antiviral immunity - PubMed
2022年2月15日 · We here find TBK1, a key kinase of antiviral pathways, phosphorylates the core m 6 A methyltransferase METTL3 at serine 67. The phosphorylated METTL3 interacts with the translational complex, which is required for enhancing …
游富平团队揭示天然免疫信号调控m6A修饰的新机制
2022年2月15日，来自北京大学基础医学院游富平团队在Cell Reports发表了题为“TBK1-METTL3 axis facilitates antiviral immunity”的研究论文，报道了天然免疫信号通路上的关键激酶TBK1可在病毒感染后与METTL3直接相互作用，并通过对METTL3功能的双重调控增强机体一型干扰素应答。...
BBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell …
2025年2月11日 · This BBOX1-DCLK2-TBK1 axis unveils an important mechanism in ccRCC metabolic dysregulation and highlights potential therapeutic strategies. ... The m6A modification-mediated OGDHL exerts a tumor ...
We here find TBK1, a key kinase of antiviral pathways, phosphorylates the core m6A methyltransferase METTL3 at serine 67. The phosphorylated METTL3 interacts with the translational complex, which is required for enhancing …
Identification of m6A-associated autophagy genes in non
2024年2月29日 · The study investigated the potential molecular mechanisms of m6A related autophagy feature genes (TBK1, RAB1A, and GOPC) in NAFLD through bioinformatic analyses and animal model validation. However, it is critical to note that these findings, although consequential, demonstrate correlations rather t …
Identification of m6A-associated autophagy genes in non …
The three m6A genes and five AGRs formed the m6A-ARGs relationship pairs. Afterwards, genes obtained from machine learning algorithms were intersected to yield three feature genes (TBK1, RAB1A, and GOPC), which showed significant positive correlation with astrocytes, macrophages, smooth muscle, and showed significant negative correlation with ...
Cell Reports揭示天然免疫信号调控m6A修饰的新机制 - 生物通
2022年2月15日，来自北京大学基础医学院游富平团队在Cell Reports发表了题为“TBK1-METTL3 axis facilitates antiviral immunity”的研究论文，报道了天然免疫信号通路上的关键激酶TBK1可在病毒感染后与METTL3直接相互作用，并通过对METTL3功能的双重调控增强机体一型干扰素应答
TBK1-METTL3 axis facilitates antiviral immunity - ResearchGate
2022年2月1日 · We here find TBK1, a key kinase of antiviral pathways, phosphorylates the core m⁶A methyltransferase METTL3 at serine 67. The phosphorylated METTL3 interacts with the translational complex, which...
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