甘露糖-6-磷酸 （英語： Mannose-6-phosphate，縮寫 M6P）是一个在 免疫系统 中与 凝集素 结合的分子，M6P可由 磷酸甘露糖异构酶 （英语：mannose phosphate isomerase） 转化为 果糖-6-磷酸。

2022年6月23日 · Among those beneficial mutations, mutation S126D increased the glucose proportion (P G) to 76%, altered the preference from M6P of WT to G6P, and improved its specificity to G6P over F6P...

经典的溶酶体定位标签是 甘露糖6-磷酸 （m6p）。这需要蛋白质中具有特定序列（asn-x-ser / thr），经内质网和高尔基体连续加工修饰产生。m6p由甘露糖受体（ mpr ）识别。mpr有两种类型（cd-mpr和ci-mpr），共同参与溶酶体蛋白的运输过程。

The cation-independent mannose 6-phosphate receptor is a multifunctional protein which binds at the cell surface to two distinct classes of ligands, the mannose 6-phosphate (M6P) bearing proteins and IGF-II. Its major function is to bind and ...

2022年8月15日 · The three critical sugar monophosphates (F6P, M6P, and G6P) as well as other SPx were taken for further optimization by column head focusing approach. One hundred % aqueous was held for 1 min, 2 min, and 3 min followed by identical gradient as before.

2003年3月1日 · The two mannose 6-phosphate (M6P) receptors were identified because of their ability to bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the endosomal–lysosomal...

2023年3月7日 · 高尔基体转运过程中，M6P 修饰的形成是溶酶体生物发生的重要标志。M6P 基团的加入，第一步由 GlcNac-1-磷酸转移酶 (GNPT；GlcNAc-1) 完成，第二步由 M6P 揭示酶 (UCE) 完成。

6-磷酸甘露糖 (M6P) 末端寡糖是 M6P 受体介导的将新合成的水解酶从高尔基体靶向溶酶体的重要信号，但由于 M6P 配体受体识别的精确结构要求尚未完全了解难以获得均质的含 M6P 的糖蛋白。 我们在这里描述了携带天然 M6P 的 N-聚糖的均质磷酸糖蛋白的化学酶促合成。 该方法包括化学合成具有不同数量和位置的 M6P 部分的聚糖恶唑啉，并通过内切糖合酶将它们转移到 GlcNAc 蛋白，以提供均质的含 M6P 的糖蛋白。 还完成了两个 M6P-寡糖与环状多肽的同时连接以产生二 …

1993年2月15日 · With 13C NMR, phosphoglucose isomerase (PGI; D-glucose-6-phosphate ketol-isomerase, EC 5.3.1.9) is shown to produce mannose 6-phosphate (M6P) slowly from a much more rapidly catalyzed equilibrium between glucose 6-phosphate (G6P) and …

2024年12月19日 · m6p受体及相关酶的表达变化可作为肿瘤标志物，用于检测肿瘤的发生与进展。 特定的M6P受体抑制剂可用于研究肿瘤细胞内的蛋白降解异常。 溶酶体酸性水解酶的作用：

抽象的 脊椎动物细胞依靠 6-磷酸甘露糖 (m6p) 修饰将大多数腔内水解酶递送至溶酶体。 作为溶酶体酶的关键运输信号，M6P 生物合成途径已被彻底研究。

在糖酵解中，葡萄糖经 己糖激酶 催化生成6-磷酸葡糖，6-磷酸葡糖进而继续参加接下来一系列的糖酵解反应。 在 戊糖磷酸途径 中，6-磷酸葡糖是该途径的起始物,经反应生成6-磷酸果糖和3-磷酸甘油醛，从而接入糖酵解途径。 此外，还生成NADPH和5-磷酸核糖，分别参与代谢和核酸合成。 ②糖合成代谢方面：在 糖异生 中，6-磷酸葡糖在 磷酸酶 的催化下生成葡萄糖，这些生成的葡萄糖又会参与糖分解代谢，重新生成6-磷酸葡糖。 综上，6-磷酸葡糖是各个糖代谢途径的共同中间 …

2014年7月14日 · The integral membrane protein LIMP-2 has been a paradigm for mannose 6-phosphate receptor (MPR) independent lysosomal targeting, binding to β-glucocerebrosidase (β-GCase) and directing it to the...

2024年6月1日 · To minimize the byproducts formation, one mannose-6-phosphate specific phosphatase (M6PP) was identified through screening and characterization of phosphatases. Ultimately, under optimized reaction conditions, the engineered strain successfully produced mannose from glucose with a high conversion rate. Fig. 1.

In concert with accessory transport proteins, this membrane-integrated enzyme catalyzes glucose production from glucose-6-phosphate (G6P) to support blood glucose homeostasis. Consistent with its metabolic function, dysregulation of G6PC1 gene expression contributes to diabetes, and mutations that impair phosphohydrolase activity form the ...

越来越多的证据表明，其中一种受体可以调节细胞的生长和运动，并且它可以起到抑癌作用。 确定了两个甘露糖6-磷酸（M6P）受体，因为它们具有结合高尔基体中含M6P的可溶性酸性水解酶并将其转运至内体-溶酶体系统的能力。 在过去的十年中，我们已经开始理解这些受体的结构特征，以使它们能够完成这项工作，以及当受体穿过各种与膜结合的隔室时如何对其进行分类。 但是贩运酸性水解酶只是故事的一部分。 越来越多的证据表明，其中一种受体可以调节细胞的生长和运 …

2019年1月1日 · Sugar phosphates with a signal-to-noise ratio >10 (G6P, DHAP, R5P, Ru5P, and Xu5P) were used for 13 C-MFA with the 13 C-labeling data of organic acids measured by GC-EI-MS to determine quantitative flux distribution (Table S1, S4).

The explanation of how are the lysosomal enzymes accurately recognized and selected over many other proteins in the trans-Golgi network relies on being tagged with a unique marker: the mannose-6-phosphate (M6P) group, which is added exclusively to the N-linked oligosaccharides of lysosomal soluble hydrolases, as they pass through the cis-Golgi ...

2018年6月7日 · We constructed glyco-engineered yeast harboring a high content of mannosylphosphorylated glycans, which can be converted to M6P glycans by uncapping of the outer mannose residue. In this study,...

Herein, for the first time, mannose-6-phosphate glycopolypeptide (M6P GP)-based bioactive and stimuli-responsive nanocarriers are reported. They are selectively taken up via receptor-mediated endocytosis, and trafficked to lysosomes where they are subsequently degraded by pH or enzymes, leading to the release of the cargo inside the lysosomes.