2024年10月11日 · 最新的研究已经证明 Maf1可以通过PI3K-AKT-mTOR信号通路负向调节海马神经元树突的生长，影响小鼠的学习和记忆能力。 目前 Maf1在中枢神经系统中已成为热门话题，通过探索Maf1在调节神经元突触中的形态学和潜在功能，有望进一步阐明突触重构的机制。 文献来源.

2024年12月25日 · MAF1 (MAF1 Homolog, Negative Regulator Of RNA Polymerase III) is a Protein Coding gene. Diseases associated with MAF1 include Hypomyelinating Leukodystrophy and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are PIP3 activates AKT signaling and Signal Transduction.

2024年2月1日 · Maf1是一种高度保守的蛋白，可作为RNA聚合酶III的转录调节因子，通过激活PTEN通路在肿瘤、糖代谢、脂质代谢等方面发挥重要作用。Maf1在中枢神经系统中也有高表达，尤其是在海马和皮层中。

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2024年4月17日 · 最新的研究已经证明Maf1可以通过PI3K-AKT-mTOR信号通路负向调节海马神经元树突的生长，影响小鼠的学习和记忆能力。目前Maf1在中枢神经系统中已成为热门话题，通过探索Maf1在调节神经元突触中的形态学和潜在功能，有望进一步阐明突触重构的机制。 文献来源

2020年7月30日 · Maf1, a general transcriptional regulator and mTOR downstream effector, is highly expressed in the hippocampus and cortex, but the function of Maf1 in neurons is not well elucidated. Here, we...

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2022年5月25日 · MAF1, a key repressor of RNA polymerase (pol) III-mediated transcription, has been shown to promote mesoderm formation in vitro. Here, we show that MAF1 plays a critical role in regulating osteoblast differentiation and bone mass. Global deletion of MAF1 (Maf1-/-mice) produced a high bone mass phenotype.

As a master regulator of transcription by RNA polymerase (Pol) III, Maf1 represses the synthesis of highly abundant non-coding RNAs as anabolic signals dissipate, as the quality or quantity of nutrients decreases, and under a wide range of cellular and environmental stress conditions. Thus, Maf1 res …

Maf1 是 RNA 聚合酶 III (Pol III) 的全局阻遏物，在真核生物。 Pol III 合成对蛋白质翻译和细胞生长至关重要的小 RNA、5S rRNA 和 tRNA。 Maf1 是一种磷蛋白，Maf1 的去磷酸化可促进其在酵母和哺乳动物中的抑制活性。