Mar 30, 2025 · MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with MALAT1 include …

MALAT1 is a highly-conserved noncoding RNA gene transcribed from the human 11q13 locus which has been shown to exhibit copy number changes, translocations, or mutations in several …

MALAT1 expression in fat tissue is positively correlated with adipogenic FABP4 and LPL. This lncRNA is involved in the regulation of PPARγ at the transcription stage, fatty acid metabolism, …

Malat1 is one of the first identified lncRNAs associated with human disease, and cumulative studies have indicated that Malat1 plays critical roles in the development and progression of …

Jan 9, 2024 · Here we show that the long noncoding RNA Malat1 is required for tumor initiation and metastatic reactivation in mouse models of breast cancer and other tumor types. Malat1 …

Oct 22, 2018 · Targeted inactivation, restoration and overexpression of MALAT1 in multiple in vivo models demonstrate that the lncRNA MALAT1 suppresses breast cancer metastasis through …

Jun 14, 2024 · We found that overexpression of Malat1 is a powerful driver of tumor progression in vivo and discovered an unanticipated paracrine mechanism by which Malat1 …

May 8, 2018 · In this review, we summarize the emerging insights on lncRNA expression and functional role in cancer, focusing on the evolutionary conserved and abundantly expressed …

Jan 1, 2024 · MALAT1 promotes cellular proliferation, epithelial-mesenchymal transition (EMT), and angiogenesis in lung cancer, collectively facilitating tumor growth and metastasis. …

MALAT1 is a highly conserved nuclear retained lncRNA that is abundantly expressed in cells and tissues and has been shown to play a role in regulating genes at both the transcriptional and …