Our results showed that MALAT1 regulates migration, proliferation and apoptosis by sponging miR-146a to regulate CXCR4 expression in AML cells, providing novel insights into the role of MALAT1 as a therapeutic target in AML.

2024年10月21日 · Our findings elucidate the intimate relationship between MALAT1 and miR-582-5P, providing insights into their coordinated regulation of AML LSCs progression. As a pivotal oncogenic signaling pathway, aberrant activation of the …

MALAT-1 knockdown inhibited the proliferation, migration and invasion of AML cells, and induced cell apoptosis; additionally, MALAT-1 binding to METTL14 promoted the m6A modification of ZEB1. Besides, ZEB1 overexpression partially reversed the effect of MALAT-1 knockdown on the cellular functions of AML cells.

hu等 研究发现敲低malat1可通过调控mir-96抑制aml细胞增殖，增强aml对阿糖胞苷的敏感性。有研究显示，malat1上调可以降低mir-328-3p的表达，而mir-328-3p降低会增加细胞周期蛋白d2（ccdn2，与癌症的耐药有关）表达，从而诱导aml对阿糖胞苷产生耐药 。以上研究证实 …

2024年11月5日 · MALAT1 modulates RAD51 activity by preventing its degradation, and silencing MALAT1 can induce synthetic lethality in AML cells when combined with PARP inhibitors. This strategy offers a novel therapeutic avenue, though careful management of specificity, toxicity, and resistance is essential for successful clinical application.

2020年7月23日 · We demonstrated that MALAT1 regulates chimeric mRNAs export in an m6A-dependent manner and thus controls hematopoietic cell differentiation. Specifically, reducing MALAT1 or m6A...

2019年4月1日 · In our study, we determined the biological functions and the underlying mechanism of MALAT1 in AML. We found that MALAT1 expression was increased in AML patients and MALAT1 knockdown inhibited proliferation and enhanced Ara-C chemosensitivity by acting as a ceRNA of miR-96 in AML cells.

2020年12月31日 · Our results showed that MALAT1 regulates migration, proliferation and apoptosis by sponging miR-146a to regulate CXCR4 expression in AML cells, providing novel insights into the role of MALAT1 as a therapeutic target in AML.

4 天之前 · MALAT1 is upregulated in AML and has been implicated in the proliferation and therapeutic resistance of leukemic cells. Its overexpression is also noted in other hematologic malignancies, such as chronic myeloid leukemia (CML) and diffuse large B-cell lymphoma, suggesting its potential as a universal biomarker and therapeutic target [ 164 ].

2024年10月21日 · Acute myeloid leukemia (AML) is characterized by uncontrolled clonal expansion and differentiation block of immature myeloid cells. Some studies have shown that leukemia stem cells (LSC) are thought to be responsible for the initiation and development of …