N6-methyladenosine modification of MALAT1 promotes …
2021年3月8日 · Here, we dissect the contribution of m 6 A to an individual-long noncoding RNA-metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). The mutant MALAT1 lacking m 6 A-motifs significantly suppressed the metastatic potential of cancer cells both in vitro and in …
N6-methyladenosine modification of MALAT1 promotes
Wang et al. reveal that N6-methyladenosine (m6A) modification of the long noncoding RNA MALAT1 is critical for the metastatic ability of cancer cells both in vitro and in vivo. MALAT1-m6A recognition by YTHDC1 regulates the composition and function of nuclear speckles, thereby amplifying cancer gene expression.
Dev Cell | 李栋课题组揭示MALAT1-m⁶A修饰的生物学功能
2021年2月21日 · 该研究综合运用长时程超分辨率活细胞成像、CUT&Tag测序和定量蛋白质组学等技术方法，揭示了lncRNA MALAT1存在m6A修饰富集区，且MALAT1-m6A对维持核斑（Nuclear Speckles）组分动态平衡，进而调控食管癌细胞的增殖和侵袭转移能力起关键作用。
The roles of N6-methyladenosine and its target regulatory
2023年3月1日 · The m6A site in MALAT1 acts as a scaffold for recruiting YTHDC1 to NSs and promotes the upregulation of key oncogenes in ESCC 94. YTHDC1 binds to the m6A site of ncRNAs to promote their...
N6-methyladenosine modification of MALAT1 promotes metastasis …
2021年3月8日 · Here, we dissect the contribution of m 6 A to an individual-long noncoding RNA—metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). The mutant MALAT1 lacking m 6 A-motifs significantly suppressed the metastatic potential of cancer cells both in vitro and in vivo in mouse.
生物物理所揭示MALAT1-m 6 A修饰的生物学功能----中国科学院
2021年2月22日 · 为阐明malat1-m 6 a如何调控侵袭转移，研究人员利用定量蛋白质谱，发现malat1-Δm 6 a能够导致几十种核斑定位蛋白在核斑上富集程度降低；利用自主开发的3d-sim超分辨显微镜和光片显微镜，系统对比了野生型和malat1-Δm 6 a细胞中rbm15、ythdc1、sf3a1、pabpn1与核斑的共 ...
李栋课题组揭示MALAT1-m6A修饰的生物学功能 - 腾讯网
2021年2月22日 · 为阐明malat1-m6a如何调控侵袭转移，作者利用定量蛋白质谱发现malat1-∆m6a能够导致几十种核斑定位蛋白在核斑上富集程度降低；同时利用自主开发的3d ...
METTL3 enhances the stability of MALAT1 with the assistance of …
2021年7月28日 · Taken together, our findings confirmed that METTL3 promoted the malignant progression of IDH-wildtype gliomas and revealed important insight into the upstream regulatory mechanism of MALAT1 and NF-κB with a primary focus on m6A modification.
Synapse-Enriched m6A-Modified Malat1 Interacts with the Novel m6A …
2023年10月25日 · RNA immunoprecipitation and mass spectrometry revealed 12 new synapse-specific learning-induced m 6 A readers in the mPFC of male C57/BL6 mice, with m 6 A-modified Malat1 binding to a subset of these, including CYFIP2 and DPYSL2.
李栋课题组揭示MALAT1-m6A修饰的生物学功能----中国科学院生 …
2021年2月20日 · 为阐明malat1-m 6 a如何调控侵袭转移，作者利用定量蛋白质谱发现malat1-Δm 6 a能够导致几十种核斑定位蛋白在核斑上富集程度降低；同时利用自主开发的3d-sim超分辨显微镜和光片显微镜系统对比了野生型和malat1-Δm 6 a细胞中rbm15、ythdc1、sf3a1、pabpn1与核斑的 …