2022年12月23日 · We show that metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a well-documented AS-implicated lncRNA, regulates AS via two SFs, polypyrimidine tract-binding protein 1 (PTBP1) and PTB-associated SF (PSF). MALAT1 stabilizes the interaction between PTBP1 and PSF, thereby forming a functional module …

2023年2月2日 · 近期，四川大学生命科学学院宋旭教授/李灵课题组在国际权威期刊 Science Advances （IF=14.957/Q1） 上发表了题为“ MALAT1 modulates alternative splicing by cooperating with the splicing factors PTBP1 and PSF ”的研究论文，该研究提出MALAT1与剪接因子PTBP1和PSF协同作用形成了影响可变剪接事件网络的功能模块，并指导PTBP1和PSF与pre-mRNA的关联，为lncRNA MALAT1在基因表达中的调控机制提供了新的见解。 奥维森提供了 …

2023年4月10日 · 近日，四川大学李灵副研究员、宋旭教授的研究团队在Science Advances上发表题为MALAT1 modulates alternative splicing by cooperating with the splicing factors PTBP1 and PSF的研究论文。...

2024年10月1日 · The upregulation of long non-coding RNA Malat1 on PSF plays a pivotal role in orchestrating osteogenic trans-differentiation through demethylation of its promoter, Yap1 signaling activation, and regulation of key miRNAs. These findings provide insights into the molecular mechanisms governing PSF's influence on cellular behavior, with potential ...

2014年9月4日 · We show that NEAT1 and MALAT1 localize to hundreds of genomic sites in human cells, primarily over active genes. NEAT1 and MALAT1 exhibit colocalization to many of these loci, but display distinct gene body binding patterns at these sites, suggesting independent but complementary functions for these RNAs.

2022年12月23日 · Here, we report that MALAT1 can stabilize interaction between the SFs polypyrimidine tract–binding protein 1 (PTBP1, also known as hnRNP I) and PTB-associated SF (PSF), thereby forming a functional module that operates in the regulation of pre-mRNA AS, and show that the functional module might be im- plicated in the pathogenesis of hepatocellula...

MALAT1 expression in fat tissue is positively correlated with adipogenic FABP4 and LPL. This lncRNA is involved in the regulation of PPARγ at the transcription stage, fatty acid metabolism, and insulin signaling. The wide range of MALAT1 functions makes it an interesting target in studies searching for drugs to prevent obesity development in ...

2022年12月23日 · We show that metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a well-documented AS-implicated lncRNA, regulates AS via two SFs, polypyrimidine tract–binding protein 1 (PTBP1) and PTB-associated SF (PSF). MALAT1 stabilizes the interaction between PTBP1 and PSF, thereby forming a functional module that affects a network of AS ...

2024年7月8日 · 利用MALAT1 作为范例，此项工作首次揭示了长非编码RNA的部分精细复杂三维结构，以及这类模块化的RNA如何通过部分模仿其他的RNA结构实现招募或者排斥不同RNA结合蛋白的原则和机制。 转移相关肺腺癌转录本1（MALAT1）是最早发现的和进化上最保守的长非编码RNA（lncRNA）之一。 MALAT1在多种癌症中的表达水平显著升高，并在预测癌症转移和患者生存方面具有重要的临床应用意义【1】。 MALAT1在 乳腺癌 、 肝癌 和 肺癌 、 糖尿病 、胰岛 …

2022年12月23日 · We show that metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a well-documented AS-implicated lncRNA, regulates AS via two SFs, polypyrimidine tract–binding protein 1 (PTBP1) and PTB-associated SF (PSF). MALAT1 stabilizes the interaction between PTBP1 and PSF, thereby forming a functional module …