Monoamine oxidase B (MAO-B) is an enzyme that in humans is encoded by the MAOB gene. The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is an enzyme located in the outer mitochondrial membrane .

血小板 mao 活性 (mao-b) 的测定显示在所有雷沙吉兰剂量水平下几乎完全抑制 mao-b。 这项研究表明，雷沙吉兰（最高 2 毫克/天）耐受性良好，与慢性 LD 治疗一起使用时，对于波动性 PD 患者具有有益的临床效果。

单胺氧化酶抑制剂（MAO inhibitor drugs，MAOID）系指能治疗与MAO 相关多种神经系统疾病的一类药物，可分为非选择性MAOID、MAO-A 抑制药物和MAO-B抑制药物。 这3类药物又可分为可逆性和不可逆性抑制药物。

mao 酶由 mao-a 和 mao-b 两种异构体组成，具有氨基酸序列、三维结构、底物偏好和抑制剂选择性等特点。多巴胺、酪胺和色胺是 mao 同种型和 mao 抑制剂（如克乐吉兰和司来吉兰）的底物，可用作神经退行性疾病和神经系统疾病的药物。

mao-b抑制剂，又称b型单胺氧化酶抑制剂，是抗帕金森药物中的一款明星产品， 司来吉兰 和 雷沙吉兰 都是mao-b抑制剂。 而MAO-B抑制剂治疗帕金森的机制包括两个方面： 保护神经，改善症状。

Monoamine oxidase-B (MAO-B) is a FAD-dependent mitochondrial enzyme, which, together with its isoenzyme MAO-A, catalyses the oxidative deamination of structurally diverse amines Kalgutkar et al (2001). MAO-B is involved in the metabolism of biogenic amines as well as amine xenobiotics Cesura and Pletscher (1992). Substrates preferential for MAO ...

Monoamine oxidase-B (MAO-B) inhibitors are commonly used for the symptomatic treatment of Parkinson’s disease (PD). MAO-B inhibitor monotherapy has been shown to be effective and safe for the treatment of early-stage PD, while MAO-B inhibitors as adjuvant drugs have been widely applied for the treatment of the advanced stages of the illness.

由于大脑中一种叫做 mao-b （单胺氧化酶 b）的酶的增加，可能会发生认知变化。 mao-b 分解 多巴胺 ，这是一种对认知功能的许多方面至关重要的神经递质。1. mao-b 的过度活动还会产生有毒化合物，这些化合物会损害脑细胞并导致神经退行性风险。1,2

它催化生物胺和外源胺的氧化脱氨作用，并在中枢神经系统和外周组织中的神经活性胺和血管活性胺的代谢中发挥重要作用。 这种蛋白质优先降解苄胺和苯乙胺。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene belongs to the flavin Monoamine Oxidase family. It is a Enzyme located in the mitochondrial outer membrane.

Monoamine oxidase B (MAO-B) enzyme is implicated in neurodegeneration, and developing inhibitors could be a promising therapeutic strategy. This review explores MAO-B activity molecular pathways, evaluates MAO-B inhibitors in neurodegenerative therapy, identifies challenges, and suggests future research directions.