Increased FAO is required for BRAFV600E -mutant melanoma cells to survive under the MAPKi-induced metabolic stress prior to acquiring drug resistance. The upfront and concomitant inhibition of FAO, glycolysis and MAPK synergistically inhibits tumor cell growth in vitro and in vivo.

2017年10月12日 · In conculsion, our findings demonstrate that hepatic p38α MAPK functions as a negative regulator of liver steatosis in maintaining BA synthesis and FAO by antagonizing the c-Jun N-terminal...

2025年1月1日 · Inhibition of FAO by CPT1 KO or Etomoxir decreases PARP1 expression, negatively regulates ADP-ribosylation modification of DUSP1 and dephosphorylates p38 MAPK which increases cell cycle gene expression and promotes cardiomyocyte proliferation.

Here we show that CD40 activation triggers fatty acid oxidation (FAO) and glutamine metabolism to promote ATP citrate lyase-dependent epigenetic reprogramming of pro-inflammatory genes and anti-tumorigenic phenotypes in macrophages.

2025年2月14日 · Dormant cancer cells switch on stress-induced signaling such as the p38 MAPK pathway, PRKR-like endoplasmic reticulum kinase (PERK), and hypoxia-inducible factors (HIFs), which facilitate drug resistance [15,16,17]. ... FAO increases the expression of ACLY, and subsequently enhances the production of acetyl-CoA, which is necessary for the ...

结果用mapki处理的黑素瘤细胞显示cd36和pparα介导的肉碱棕榈酰转移酶1a（cpt1a）依赖性脂肪酸氧化（fao）水平升高。尽管cd36是适应性和耐药性阶段黑色素瘤细胞的有用标志物，但cd36的上调在功能上并未参与表征mapki处理的细胞的fao变化。

Mitogen-activated protein kinase (MAPK) cascades and the calcium–calcineurin pathway control fundamental aspects of fungal growth, development and reproduction. Core elements of these signalling pathways are required for virulence in a wide array of …

In this study, we identified five MAPK pathway‐related phosphatases (Msg5, Yvh1, Ptp1, Ptp2 and Oca2) and characterized their functions in Aspergillus flavus, which produces aflatoxin B₁ (AFB₁), one of the most toxic and carcinogenic secondary metabolites.

2023年1月14日 · 丝裂原活化蛋白激酶 (mitogen-activated protein kinase，MAPK)级联系统是真核生物细胞中高度保守的信号系统之一，参与诸多生物学过程的调控。 在细胞因子、神经递质及激素等不同信号的刺激下，MAPK级联逐步激活下游靶因子，控制着多种细胞过程，包括生长、免疫、炎症和应激反应等。 在不同细胞中，MAPK级联对细胞的作用随刺激物与刺激持续时间的不同而有 …

The mitogen-activated protein kinase (MAPK) cascade transfers the signals perceived by cell membrane surface receptors to cells through phosphorylation and dephosphorylation and targets various effector proteins or transcriptional factors so as to result in the stress response.