SIRT和AMPK靶点通路知识讲解 - 知乎 - 知乎专栏
sirt6：在具有较高传代次数的人真皮成纤维细胞中，sirt1和sirt6的表达水平均下降，且两者水平与已知的衰老相关的生物标志物有关。 因此，提高真皮成纤维细胞中SIRT1和SIRT6的水平会逆 …
SIRT6 haploinsufficiency induces BRAFV600E melanoma cell
2018年8月24日 · Combining a clinically applicable IGF-1Ri with BRAFi overcomes resistance of SIRT6 haploinsufficient melanoma cells in vitro and in vivo. Using matched melanoma …
Emerging Roles of SIRT6 in Human Diseases and Its Modulators
The biological functions of SIRT6 (e.g. deacetylation, defatty-acylation and mono-ADP-ribosylation) play a pivotal role in regulating lifespan and several fundamental processes …
Emerging Therapeutic Potential of SIRT6 Modulators - PMC
Sirtuin 6 (SIRT6) is an NAD+-dependent protein deacylase and mono-ADP-ribosyltransferase of the sirtuin family with a wide substrate specificity. In vitro and in vivo studies have indicated …
SIRT6 haploinsufficiency induces BRAFV600E melanoma cell …
2018年8月24日 · Combining a clinically applicable IGF-1Ri with BRAFi overcomes resistance of SIRT6 haploinsufficient melanoma cells in vitro and in vivo. Using matched melanoma …
SIRT6: Novel Mechanisms and Links to Aging and Disease
2017年3月1日 · SIRT6, a member of the Sirtuin family of NAD +-dependent enzymes, has established roles in chromatin signaling and genome maintenance. Through these functions, …
SIRT6 Inhibits the Proliferation and Collagen Synthesis of Keloid ...
SIRT6 overexpression in keloid fibroblasts attenuates proliferation, invasion, and collagen synthesis, while fostering apoptosis, likely through the suppression of MAPK/ERK pathway …
Endogenous SIRT6 in platelets negatively regulates platelet
2023年12月18日 · Mechanistically, we have identified that SIRT6 deficiency in platelets leads to the enhanced expression and release of proprotein convertase subtilisin/kexin type 9 …
Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 ...
2023年8月4日 · In this study, we investigated the effect of SIRT6 on PI3K/AKT/mTOR and MAPK/ERK pathways in BXPC-3 cells. As depicted in Fig. S3 , the acetylation level of histone …
Endogenous SIRT6 in platelets negatively regulates platelet …
2023年12月17日 · SIRT6 inhibits thrombin-induced platelet activation by suppressing platelet-derived PCSK9 secretion and subsequent MAPK signaling transduction. These findings …