sirt6：在具有较高传代次数的人真皮成纤维细胞中，sirt1和sirt6的表达水平均下降，且两者水平与已知的衰老相关的生物标志物有关。 因此，提高真皮成纤维细胞中SIRT1和SIRT6的水平会逆转随时间变化的衰老进程。

2018年8月24日 · Combining a clinically applicable IGF-1Ri with BRAFi overcomes resistance of SIRT6 haploinsufficient melanoma cells in vitro and in vivo. Using matched melanoma samples derived from patients...

The biological functions of SIRT6 (e.g. deacetylation, defatty-acylation and mono-ADP-ribosylation) play a pivotal role in regulating lifespan and several fundamental processes controlling aging such as DNA repair, gene expression, and telomeric ...

Sirtuin 6 (SIRT6) is an NAD+-dependent protein deacylase and mono-ADP-ribosyltransferase of the sirtuin family with a wide substrate specificity. In vitro and in vivo studies have indicated that SIRT6 overexpression or activation has beneficial ...

2018年8月24日 · Combining a clinically applicable IGF-1Ri with BRAFi overcomes resistance of SIRT6 haploinsufficient melanoma cells in vitro and in vivo. Using matched melanoma samples derived from patients receiving dabrafenib + trametinib, we identify IGFBP2 as a potential biomarker for MAPKi resistance.

2017年3月1日 · SIRT6, a member of the Sirtuin family of NAD +-dependent enzymes, has established roles in chromatin signaling and genome maintenance. Through these functions, SIRT6 protects against aging-associated pathologies including metabolic disease and cancer, and can promote longevity in mice.

SIRT6 overexpression in keloid fibroblasts attenuates proliferation, invasion, and collagen synthesis, while fostering apoptosis, likely through the suppression of MAPK/ERK pathway activity. This suggests a potential therapeutic target for keloid treatment.

2023年12月18日 · Mechanistically, we have identified that SIRT6 deficiency in platelets leads to the enhanced expression and release of proprotein convertase subtilisin/kexin type 9 (PCSK9), subsequently activating the platelet activation-associated mitogen-activated protein kinase (MAPK) signaling pathway.

2023年8月4日 · In this study, we investigated the effect of SIRT6 on PI3K/AKT/mTOR and MAPK/ERK pathways in BXPC-3 cells. As depicted in Fig. S3 , the acetylation level of histone H3 was significantly...

2023年12月17日 · SIRT6 inhibits thrombin-induced platelet activation by suppressing platelet-derived PCSK9 secretion and subsequent MAPK signaling transduction. These findings provides valuable mechanistic insights into the intricate interplay between endogenous SIRT6 and platelet function, shedding light on potential therapeutic avenues for thrombotic disorders.