Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene. [5] The protein encoded by this gene is a member of the MAP kinase family.

2024年12月25日 · MAPK1 (Mitogen-Activated Protein Kinase 1) is a Protein Coding gene. Diseases associated with MAPK1 include Noonan Syndrome 13 and Specific Learning Disability. Among its related pathways are Prolactin Signaling and Toll Like Receptor 7/8 (TLR7/8) Cascade.

Mitogen activated protein kinase 1 (MAPK1) was significantly up-regulated, while miR-422a was down-regulated in thyroid cancer cells cultured with high iodine; miR-422a directly bound to the 3'UTR of MAPK1 mRNA.

Since ERK1 and its close relative ERK2 (MAPK1) are both involved in growth factor signaling, the family was termed "mitogen-activated".

2025年2月20日 · Clinical resource with information about MAPK1, Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis., Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease., Noonan syndrome 13, …

Saba-El-Leil et al. (1997) mapped the mouse Mapk1 gene to chromosome 16, in a region showing homology of synteny with human 22q11.2. ERKs are also known as maturation- or mitogen-activated protein (MAP) kinases. Cobb et al. (1991) provided a review.

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF.

MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.

MAPK1, also known as ERK2, is a protein kinase that is part of the ERK1/2 MAPK pathway. It is involved in phosphorylating various substrates in the cytoplasm and nucleus, playing a crucial role in processes such as proliferation, survival, migration, and fate choice in cells.

Mitogen-activated protein kinases (MAPKs) are protein Ser/Thr kinases that convert extracellular stimuli into a wide range of cellular responses. MAPKs are among the most ancient signal transduction pathways and are widely used throughout …