The lectin pathway or MBL pathway is a type of cascade reaction in the complement system, similar in structure to the classical complement pathway, [1] in that, after activation, it proceeds through the action of C4 and C2 to produce activated …

MBL in the blood is complexed with (bound to) a serine protease called MASP (MBL-associated serine protease). There are three MASPs: MASP-1, MASP-2 and MASP-3, which have protease domains. There are also sMAP (also called MAp19) and MAp44, which do not have protease domains and are thought to be regulatory molecules of MASPs.

Mannose-binding lectin (MBL) is a serum component which participates in innate immunity by activating complement via a novel pathway. Human MBL forms complexes with two types of serine proteases termed MASP (MBL-associated serine protease). These two proteases, MASP1 and MASP2, are structurally simi …

Mannose Binding Lectin (MBL)是一种识别多甘露糖结构的蛋白多聚物。 MBL合成于肝脏，由三个相同单体聚合而成一个subunit， 并可以进一步通过N端collagen domain形成二硫键多聚。

2024年12月25日 · MASP1 (MBL Associated Serine Protease 1) is a Protein Coding gene. Diseases associated with MASP1 include 3Mc Syndrome 1 and 3Mc Syndrome. Among its related pathways are Initial triggering of complement and Complement cascade. Gene Ontology (GO) annotations related to this gene include calcium ion …

该蛋白不直接参与补体激活，但可能通过切割补体 C2 或通过激活另一种补体丝氨酸蛋白酶 MASP-2 发挥补体激活放大器的作用。 编码的蛋白质还能够切割纤维蛋白原和因子 XIII，并可能参与凝血。 该基因的剪接变体缺少丝氨酸蛋白酶结构域，可作为补体途径的抑制剂发挥作用。 交替剪接导致多个转录变体。 [RefSeq 提供，2010 年 4 月] This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation.

2008年5月1日 · In the lectin complement pathway, mannose-binding lectin (MBL) and ficolins act as recognition molecules, and MBL-associated serine protease (MASP) is a key enzyme. It has been suggested that MASP-2 is responsible for the activation of C4.

The lectin pathway of the complement system has a pivotal role in the defense against infectious organisms. After binding of mannan-binding lectin (MBL), ficolins or collectin 11 to carbohydrates or acetylated residues on pathogen surfaces, dimers of …

补体激活的途径之一，由血浆中甘露聚糖结合凝集素（mannan-binding lectin,MBL）直接识别多种病原微生物表面的N-氨基半乳糖或甘露糖，进而依次活化MASP-1、MASP-2、C4、C2、C3，形成和经典途径相同的C3与 C5转化酶 ，激活补体级联酶促反应的活化途径。MBL激活途径的 ...

2002年1月1日 · Subsequently a homologue of C1r and C1s was found associated with MBL, and was named “MASP” (MBL-associated serine protease) (8), and it was shown that this protease, and not C1s, appeared to mediate complement activation stimulated by MBL binding to a target.