2024年12月25日 · MBP (Myelin Basic Protein) is a Protein Coding gene. Diseases associated with MBP include Secondary Progressive Multiple Sclerosis and Demyelinating Disease. Among its related pathways are Nervous system development and CNTF Signaling.

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system.

Gene ID: 4155, updated on 9-Feb-2025. The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system.

This gene encodes a signal sequence that can direct MBP to the bacterial periplasm.

2014年3月1日 · 人脑髓鞘碱性蛋白（英文：Myelin basic protein，简称MBP）是一种相信对在中央神经系统的神经 髓鞘化过程非常重要的蛋白质。 MBP在与髓鞘膜隔离后，首先于1979年进行 测序 。

2023年5月14日 · 髓鞘碱性蛋白（MBP）是构成中枢神经系统髓鞘的主要蛋白质，约占髓鞘总蛋白的30%。 MBP是反映中枢神经系统是否有实质性损伤，特别是髓鞘丢失的诊断指标。 当中枢神经系统发生病变时 (如感染、炎症、肿瘤、外伤、出血、水肿等)，可通过测定脑脊液中的髓鞘碱性蛋白（MBP）的变化，作为临床诊断、治疗疾病和预后观察的依据。 脑髓鞘碱性蛋白（Myelin basic protein，MBP）是一种相信对在中央神经系统的神经髓鞘化过程非常重要的蛋白质。 MBP …

2024年12月10日 · The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system.

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis.

The myelin basic protein (MBP) gene was initially described as coding for proteins that are major constituents of the myelin sheath of oligodendrocytes in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS).

The MBP gene is very large (>100 kb) and contains three transcription start sites, generating mRNAs that encode two families of proteins: classic MBPs and golli MBPs (Campagnoni et al., 1993; Pribyl et al., 1993). The classic MBPs are the products of transcription start sites 2 and 3 and are well known as major protein constituents of the ...