2023年2月23日 · We find macroH2A variants localized at enhancer elements that are devoid of H3K27ac in a cell type-specific manner, indicating a role for macroH2A at inactive enhancers …

2024年8月22日 · Genome-wide analyses demonstrate that FACT-mediated depletion of macroH2A-nucleosomes allows the correct localization of macroH2A, while the S139 mutation …

2022年5月19日 · MacroH2A (mH2A) is an especially strong candidate based on its unique structure among histones. In addition to its histone domain that shares 64% similarity with the …

macroH2A is an H2A variant with a highly unusual structural organization. It has a C-terminal domain connected to the N-terminal histone domain by a linker. Crystallographic and …

2017年4月6日 · Here, by studying spermatogenesis in the absence of a spermatid-specific histone variant, H2A.L.2, we discover a fundamental mechanism involved in the transformation …

Here we report the identification of MACROH2A2, a new MACROH2A subtype encoded by a separate gene on human chromosome 10, MACROH2A2. The amino acid sequence of human …

Here, we focus on the family of macroH2A histone variants that are particular in having a tripartite structure consisting of a histone fold, an intrinsically disordered linker and a globular …

2019年4月23日 · MacroH2A is an unusual histone variant with a bulky C-terminal non-histone domain that distinguishes it from all other histones. It is a critical player in stabilizing …

本文在概述组蛋白变体和H2A.Z发展史的基础上，重点阐述了H2A.Z不同亚型、不同翻译后修饰和基因组分布在转录调控过程中的作用，明确了其生物学意义和在肿瘤发生发展、神经系统分化 …

组蛋白2A变异体 (histone family 2A variant，H2AX)在DNA双链断裂 (double-strand break, DSB)损伤时可以发生不同的翻译后修饰，包括磷酸化、乙酰化、甲基化和泛素化。 通过这些修 …