The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor, is a G protein–coupled receptor that binds to a class of pituitary peptide hormones known as the melanocortins, which include adrenocorticotropic hormone (ACTH) and the different forms o...

MC1R是在 黑色素细胞 中生成黑色素的关键控制器。 当α-MSH刺激MC1R时，它通过腺苷酸环化酶（AC）激活产生cAMP。 cAMP进而激活PKA，PKA通 过CREB的磷酸化激活 MITF 的基因表达。 最后通过与 TYR，TRP-1和TRP-2启动区域相互作用，MITF基因转录生成黑色素相关的蛋白。 一旦α-MSH与MC1R结合，黑色素原生成增加100 倍 。 ☆ Wnt信号通路. Wnt配体与受体Frizzled结合激活后，一系列复杂的反应会引起β-连环蛋白（β-catenin）在细胞内的积累。 在这个通道 …

The MC1R gene provides instructions for making a protein called the melanocortin 1 receptor. This receptor plays an important role in normal pigmentation. The receptor is primarily located on the surface of melanocytes, which are specialized cells that produce a pigment called melanin.

2016年5月30日 · The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that regulates skin pigmentation, UV responses, and melanoma risk. It is a hi...

黑素皮质素受体1 (MC1R)是一种 G蛋白耦合受体，长度约为310个 氨基酸 左右，其 基因序列 只有一个 外显子, 有7个 跨膜结构域, 是最小的G蛋白耦合受体 [7]。

2024年12月25日 · MC1R (Melanocortin 1 Receptor) is a Protein Coding gene. Diseases associated with MC1R include Skin/Hair/Eye Pigmentation, Variation In, 2 and Melanoma, Cutaneous Malignant 5. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

In this review, we focus on the melanocortin 1 receptor (MC1R), a G protein-coupled receptor primarily known for regulating skin pigmentation and exhibiting anti-inflammatory effects. First, we provide an overview of the structure, signaling pathways, and related diseases of MC1R.

黑色素皮质素1受体（MC1R），也被称为黑色素细胞刺激素受体（MSHR）、黑色素激活肽受体或黑色素皮质素受体，是一种G蛋白偶联受体，与被称为黑色素皮质素的一类垂体肽激素结合，其中包括促肾上腺皮质激素（ACTH）和不同形式的黑色素细胞刺激素（MSH）。

黑皮质素 1 受体 (MC1R) 是一种 G 蛋白偶联受体，在人类和小鼠色素沉积中起着至关重要的作用。 α-黑素细胞刺激素 (α-MSH)激活黑素细胞中的MC1R可刺激cAMP信号传导和黑色素生成，并增强紫外线照射后的DNA修复。

The melanocortin 1 receptor (MC1R) gene encodes the receptor of melanocortin-stimulating hormone (also referred to as melanocyte -stimulating hormone or MSH), which is found on the …