Structure and pKa value of DLin-MC3-DMA (A), SM-102 (B
The pKa value of a ionizable compound defines the pH at which its functional ionizable groups are 50% in ionized and 50% in a de-ionized form.
表观PKa在包裹siRNA和mRNA的纳米粒子研制中的重要性 - 知乎
通过系统地改变1，2-二苯氧基-3-二甲氨基丙烷(DLinDMA)的结构，采用合理的设计方法开发了MC3脂质。 每条尾巴上的两个双键是DLinDMA高 基因沉默 活性的原因。
Ionization and structural properties of mRNA lipid nanoparticles ...
2021年8月11日 · Lipid Nanoparticles (LNPs) are used to deliver siRNA and COVID-19 mRNA vaccines. The main factor known to determine their delivery efficiency is the pKa of the LNP …
DLin-MC3-DMA (CAS 1224606-06-7) - Cayman Chem
DLin-MC3-DMA is an ionizable cationic lipid (apparent pK a = 6.44) that has been used in the generation of lipid nanoparticles (LNPs) encapsulating siRNA, mRNA, or plasmid DNA for use …
Difference in the lipid nanoparticle technology employed in …
All 3 ionizable lipids have tertiary amine group with pKa 6.0–6.7. These lipids switch its charge from neutral to cationic based on the neutral pH in the blood and the acidic pH in endosomes. …
阳离子脂质体DLin-MC3-DMA详解 - ChemicalBook
2021年4月8日 · DLin-MC3-DMA作为新型阳离子脂质——可电离化阳离子脂质，具有“低毒高效”的优势，随全球shou个siRNA脂质体产品Onpattro的在美上市而备受关注。它的化学名为4-(N,N- …
The Importance of Apparent pKa in the Development of …
An apparent pKa range of 6-7 is the optimum range for the development of highly efficient nanoparticles for RNA delivery. The nanoparticles with lower pKa values do not have enough …
pKa of Lipids in Drug Delivery - BroadPharm
2024年3月13日 · Ionizable Lipid D-Lin-MC3-DMA (pKa 6.44) For maximizing the potency of hepatic delivery of siRNAs, LNPs with an optimized pKa in the range of 6.2 to 6.4 prove …
2023年2月28日 · Ionizable lipids such as the promising Dlin-MC3-DMA (MC3) are essential for the successful design of lipid nanopar- ticles (LNPs) as drug delivery agents. Combining …
mRNA脂质递送载体LNP的处方分析（可电离脂质） - 知乎
疏水性尾部会影响pKa，亲脂性，流动性和融合性，从而影响LNP的形成和效力。 可电离脂质通常含有1~4条疏水尾部，其中包含8~20个碳原子。 尾部可以是饱和/或不饱和的脂肪链（图2）， …