The intrinsic immunogenic properties of cancer cell lines
2020年11月19日 · In C57BL/6 mice and its derived cancer cell lines MC38 and B16, the other gene product, p15E, deriving from the gp70-precursor protein, has been shown to also give …
Organoid Modeling of the Tumor Immune Microenvironment
ALI organoids were also robustly generated from mouse tumors implanted subcutaneously (s.c.) into syngeneic immunocompetent hosts: mouse B16 melanoma transduced with SIY peptide …
Tumor immunogenicity dictates reliance on TCF1 in CD8 - Cell Press
2023年9月11日 · To examine how the defect in early TCF1 cKO T cell activation in the TDLN affected intra-tumoral CD8 + T cell responses and ICB efficacy, we implanted WT or TCF1 …
Granzyme B nanoreporter for early monitoring of tumor …
2020年10月2日 · To test whether GNRs can enable monitoring of anti–PD-L1 treatment in real time, we performed efficacy studies in two different tumor models: WT-B16/F10 melanoma …
Nature Med. | 八种肿瘤模型中免疫宏观环境系统功能障碍和可塑性 …
研究人员首先研究了八种小鼠肿瘤模型 (乳腺癌模型：4T1、AT3、MMTV；黑色素瘤模型：B16、Braf；胰腺癌模型：LMP；结肠癌模型：MC38；胶质母细胞：SB28)的 TME。 研究发现，不 …
MC38 colorectal tumor cell lines from two different sources …
Here, we re-sequenced exomes and transcriptomes of MC38 cells from two different sources, namely Kerafast (originating from NCI/NIH, MC38-K) and the Leiden University Medical Center …
A next-generation tumor-targeting IL-2 preferentially promotes …
2019年8月28日 · We propose that lack of IL-2 limits the proper expansion of antigen-specific T cells (SIY-reactive T cells in the B16-SIY model and OVA-reactive T cells in MC38-OVA …
A novel peptide targeting CCR7 inhibits tumor cell lymph node ...
3 天之前 · Correspondingly, CCL19 induced the migration of MC38-CCR7 (GFP) tumor cells in vitro, but TC6-D3 peptide depressed the effects of CCL19. Based on these results, we …
Targeting tumor-intrinsic S100 calcium-binding protein A1
5 天之前 · Furthermore, the level of p65 ubiquitination was attenuated in LLC S100a1 KD cells, whereas S100a1 OE MC38 cells exhibited a higher amount of ubiquitinated p65 compared to …
The m6A revolution: transforming tumor immunity and enhancing ...
2025年2月22日 · Treatment with Dac51, a potent inhibitor of FTO, has been shown to enhance T cell infiltration and synergistically augment the effects of anti-PD-L1 blockade, as evidenced by …