2022年9月6日 · To elucidate the T cell immune microenvironment of lactate-augmented anti-tumor immunity, we analyzed CD3 + T cells from MC38 tumors and tumor draining lymph nodes (DLNs) using single cell RNA...

2022年9月6日 · To this end, CTLs were exposed to TDFs produced by MC38 colon adenocarcinoma cells and present within the tumor cell-conditioned media (TCM), as well as to purified factors such as prostaglandin E2 (PGE 2) and vascular endothelial growth factor (VEGF), which are known to contribute to the immune suppressive properties of the tumor ...

Immunohistochemistry of MC38 Tumors: Detection of CD3+ T Cells and PD-L1+ Cells on the Tumor Perimeter and Interior. C57BL/6 mice bearing MC38 tumors (n = 4–5 mice/group) were treated on days...

2025年1月9日 · In MC38-tumors in mice, MATE-expression by the oncolytic adenovirus Ad5/11 facilitated intratumoral T-cell activation, reduced tumor growth and prolonged survival accompanied by infiltration of tumor-directed CD8 + T cells and improved CD8/CD4 T-cell ratio.

2024年4月12日 · Here, we show that ITPRIPL1 functions as an inhibitory ligand of CD3ε, and its expression inhibits T cells in the tumor microenvironment. The binding of ITPRIPL1 extracellular domain to CD3ε on T cells significantly decreased calcium influx and ZAP70 phosphorylation, impeding initial T cell activation.

2021年11月1日 · We found that the durable antigen-specific T-cell responses resulted from the rejuvenation of CD8 T cells, owing to the blockade of PD-L1 on dendritic cells (but not on tumour cells) and...

CD3分子是T细胞膜上重要的生物标志物，由四条蛋白质链（CD3γ，CD3δ，CD3ε和CD3ζ）组成， 其中CD3ε对T细胞活化以及T细胞发育至关重要。 CD3ε和CD3γ、CD3δ的细胞外结构域结合形成2对异二聚体（CD3γε和CD3δε）。 鉴于T细胞受体（TCR）的αβ亚基胞内区很短，不能独立完成信号转导功能， T细胞的信号转导需要CD3和TCR形成的复合体才能完成。 当 TCR/CD3复合体 受到抗原刺激时，CD3胞内区尾部的构象发生变化。 Src家族蛋白酪氨酸激酶 （PTKs）磷酸 …

2024年1月2日 · CD3 bispecific antibody (bsAb) therapy is becoming an increasingly prevalent modality in the field of cancer treatment. These bsAbs simultaneously bind to a tumor-associated surface antigen with...

2024年1月18日 · We show that the crosstalk between conventional type I dendritic cells (cDC1) and T cells is essential for an effective aPD-1-mediated anti-tumor response. Accordingly, we developed a bispecific DC-T cell engager (BiCE), a reagent that facilitates physical interactions between PD-1 + T cells and cDC1.

2024年8月20日 · The anti-tumor effects of IMT030122 were evaluated in an immunocompetent CD3-4-1BB dual-humanized mouse model of mouse colorectal cancer, MC38-hEpCAM. The experimental procedure is illustrated in Fig. 5 A.