2021年12月1日 · The results of our study indicate that obesity contributes to lung metastasis in the MC38 colon cancer cells and that the Fas signaling in adipocytes promotes lung metastasis via the upregulation of TNF-α through the Fas/Bmx interaction in obesity. We also found that Fas signaling activation promoted the systemic inflammation in mice.

2021年12月1日 · In this study, we found that the increased tumor necrosis factor-alpha (TNF-α) in adipocytes promoted the lung metastasis of MC38 colon cancer cells via Fas signaling.

2019年2月1日 · Fas expression level in subsets of colon cancers was compared in murine colon carcinoma CT26, MC32a, and MC38 cell lines and human colon carcinoma HCT116 and SW480 cell lines. CD133 + and CD24 lo were used to define the phenotype of colon CSC-like cells ( …

2021年1月8日 · To confirm the role of reprogramming MDSCs by activated T cells in vivo, we tested the effect of PD-1 mAb on the survival and function of tumor-infiltrating myeloid cells in an ICB-responsive...

2020年10月20日 · The improved outcome of MC38-OT I tumors treated with GW6471-PD-L1 antibody combination therapy prompted us to test whether DCs play a major role in this anti-tumor effect. MC38-OT I tumors were injected in CD11c-diphtheria toxin receptor (CD11c-DTR) chimeric mice, which lack CD11c + DCs under DT administration (Figure 7A).

2016年4月18日 · In this study, we report that monocytes/macrophages induce S100a8 and S100a9 messenger RNA (mRNA) expression in cancer cells in an extracellular signal-related kinase (ERK)-dependent manner. S100A8...

2003年6月15日 · Treatment of carcinoembryonic Ag-expressing MC38 adenocarcinoma cells with irradiation (20 Gy) in vitro enhanced Fas expression at molecular, phenotypic, and functional levels. Furthermore, irradiation sensitized these targets …

MC38细胞表达claudin-1和SATB2等结肠标志物，这对于研究结肠腺癌的基因组和表观基因组以及探寻潜在的治疗手段至关重要。 MC38异种移植模型的免疫学特性使其成为癌症研究的通用工具。

mc38异种移植模型的免疫学特性使其成为癌症研究的通用工具。 物种：小鼠，C57BL/6品系；雌性 组织：结肠；疾病：结肠腺癌

Infection of FasR+ normal and MC38 cancer cells by vFasL led to abortive viral replication owing to acute apoptosis and subsequently showed both reduced pathogenicity in non-tumor-bearing mice and reduced efficacy in FasR+ tumor-bearing mice.