Immunohistochemistry of MC38 Tumors: Detection of CD3+ T …
C57BL/6 mice bearing MC38 tumors (n = 4–5 mice/group) were treated on days 7, 10, and 13 with the indicated antibodies. Tumors were harvested on day 14 and processed for IHC. …
JCI - Remodeling the tumor microenvironment via blockade of …
2022年3月1日 · Trichrome and immunohistochemistry (IHC) staining of MC38 tumors with biotinylated NC410 demonstrated high collagen content and binding of NC410 to collagen-rich …
Dynamic differentiation of F4/80+ tumor-associated macrophage …
2023年2月13日 · Immunohistochemistry (IHC) with anti-GFP or anti-S100A4 antibodies tracing of Mc38 cells in varied stages showed a replacement growth pattern of CRLM (A) and positive...
The liver microenvironment orchestrates FGL1-mediated immune …
2023年10月23日 · To identify key immunosuppressive molecules that promote CRC progression in the liver microenvironment, we first constructed a liver metastasis mouse model of murine …
Tumour and host cell PD-L1 is required to mediate suppression …
2017年2月21日 · CT26 and MC38 are two immunogenic 14, 15 colon tumour models that demonstrate PD-L1 expression on tumour cells as well as tumour infiltrating immune cells in …
Comparison of the molecular and cellular phenotypes of common …
2020年1月2日 · The high mutational load of CT26 and MC38 models may represent specific hypermutated human colon tumors. Overall, these models could represent human tumor …
Late-stage MC38 tumours recapitulate features of human …
MC38 colon adenocarcinoma is a widely used preclinical model, yet how it recapitulates human colorectal cancer remains poorly defined. This study investigated the tumour-T cell immune …
Spatial organization of immune cells in subcutaneous MC38...
Spatial organization of immune cells in subcutaneous MC38 tumours Representative micrographs of H&E and indicated IHC stains of subcutaneous MC38 tumours. Arrows indicate positive …
Eradication of Tumors through Simultaneous Ablation of …
2017年4月10日 · We established conditional (temperature-dependent) immortalized MC38-derived colon TECs (M-TECs), by isolating CD31 + CD276 + TECs from MC38 tumors (Figure …
Immunohistochemistry (IHC) MC38 tumors were collected and snap frozen from the 5 surviving animals in each group on day 5 after oxaliplatin plus anti–programmed death-ligand-1 (OP) or …