Endogenous retroviral proteins provide an immunodominant …
2020年5月13日 · Our query identified that multiple expanded TCR clones recognized the retroviral epitope p15E as an immunodominant antigen. In addition, we found that the endogenous retroviral genome encoding for p15E is highly expressed in MC38 tumors, but not in normal tissues, due to epigenetic derepression.
Nature cancer | 免疫检查点阻断与新抗原疫苗联合治疗可有效控制 …
2022年4月18日 · 近期，在 nature cancer 杂志上发表了一篇名为“ Concurrent delivery of immune checkpoint blockade modulates T cell dynamics to enhance neoantigen vaccine-generated antitumor immunity ”的文章，利用 MC38模型 来研究新抗原疫苗接种、抗PD-L1治疗和联合治疗期间的T细胞动力学，首次在人类身上复制了这一观察结果，表明联合治疗比单独接种疫苗能产生更好的抗肿瘤效果。 为了研究新抗原疫苗诱导的T细胞反应和体内抗肿瘤效应，首先对小鼠结直 …
The intrinsic immunogenic properties of cancer cell lines
2020年11月19日 · In C57BL/6 mice and its derived cancer cell lines MC38 and B16, the other gene product, p15E, deriving from the gp70-precursor protein, has been shown to also give rise to antigen-specific CTLs...
An oncolytic virus delivering tumor-irrelevant bystander T cell ...
2024年4月12日 · Further examination of endogenous CD8 + T cells specific to the MC38 tumor antigen p15E by both tetramer staining and a relevant peptide stimulation assay highlighted the reinforced...
Concurrent intratumoural T - Nature
2024年12月2日 · MC38 tumours on days 7, 14 and 21 exhibited distinct TME features representing early, intermediate and late-stage tumours 15. In this study, tumours at days 7 and 14 were utilized to mimic ...
Identification of Enhanced Vaccine Mimotopes for the p15E …
2024年4月4日 · p15E-3C, p15E-3M, and p15E-3C2V e-mimotopes were superior to the wild-type peptide for inducing cytotoxic CD8 + T cells reactive against the wild-type p15E epitope and inhibiting prophylactic MC38 or B16-F10 tumor growth. In therapeutic challenges, these immunogenicity-improved mimotope vaccines were found unable to fully reject tumor growth ...
Immunization against Endogenous Retroviral Tumor-associated …
Tumor-infiltrating lymphocyte cultures obtained from a methylcholanthrene-induced fibrosarcoma and MC-38 were shown to recognize p15E in a H-2K b-restricted fashion. Furthermore, p15E-specific CTL lines generated from splenocyte cultures by in vitro peptide stimulation were reactive against several p15E-expressing tumor lines. However, there ...
Nat Cancer | 免疫检查点阻断的同时传递调节T细胞动态，以增强新 …
2024年3月18日 · 为了研究新抗原疫苗诱导的t细胞反应和体内抗肿瘤效果，作者首先在小鼠结肠癌模型mc38上进行了新抗原疫苗治疗，该模型具有明确定义的mhc-i限制性免疫原新抗原。
Our query identified that multiple expanded TCR clones recognized the retroviral epitope p15E as an immunodominant antigen. In addition, we found that the endogenous retroviral genome encoding for p15E is highly expressed in MC38 tumors, but not in normal tissues, due to epigenetic derepression.
JCI - HDACi promotes inflammatory remodeling of the tumor ...
2022年8月16日 · Since MC38 tumor cells share an endogenous antigen with B16F10 in the expression of p15E (37, 38), we wondered whether ACT+MS-275–driven p15E responses alone could facilitate tumor rejection. In mice that were cured of B16-gp33 tumors during ACT+MS-275 treatment, rechallenge with parental MC38 tumors resulted in delayed tumor growth and ...