MCT2 is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactic acid, branched-chain oxo acids derived from leucine, valine, and isoleucine, and the ketone bodies acetoacetate and beta-hydroxybutyrate. It also functions as high- affinity pyruvate transporter.

We have molecularly cloned and characterized a novel human monocarboxylate transporter, MCT2. The cDNA is 1,907 base pairs long and encodes a polypeptide of 478 amino acids with 12 predicted transmembrane domains. Human MCT2 is the product of a single gene that mapped to chromosome 12q13 by fluorescence in situhybridization.

Especially in cancer, MCT1, MCT2, and MCT4 are considered attractive targets to inhibit lactate shuttling and thereby interfering with tumor energy metabolism.93 For instance, the anticancer drug lonidamine is especially effective in sensitizing tumor cells to other chemotherapeutic agents and this activity can be attributed, in part, to ...

2003年1月1日 · Using a novel MCT2 antibody we have shown that MCT2 is concentrated in the postsynaptic density of synapses between parallel fibres and Purkinje cell spines (Bergersen et al., 2001). We have also shown that MCT4 is preferentially expressed in astrocytes (Bergersen et al., 2001) including the astrocytic processes that ensheath the latter type of ...

图2 MCT1的主要功能功能是再慢肌纤维等氧化能力强的组织中吸纳乳酸进行氧化. 运动对MCT1的影响，已成为运动生理生化界关注的热门课题之一。 动物实验业已证实，耐力训练可使白鼠MCT1增加，即使在滚轮式动物炮台上自由运动的白鼠中，运动量与足底肌的MCT1含量呈正相关。 同时发现，MCT1越多，运动中生成的乳酸越少，即血乳酸与肌肉MCT1含量呈负相关，表明，MCT1的确能促使运动中产生的乳酸及时被氧化，致使血乳酸浓度下降 (见图3) 图3 白鼠足 …

2020年5月15日 · To discover how MCTs solve this fundamental aspect of intracellular monocarboxylate homeostasis in the context of multicellular organisms, we analyzed pyruvate transport activity of human...

1998年10月30日 · We have molecularly cloned and characterized a novel human monocarboxylate transporter, MCT2. The cDNA is 1,907 base pairs long and encodes a polypeptide of 478 amino acids with 12 predicted transmembrane domains. Human MCT2 is the product of a single gene that mapped to chromosome 12q13 by fluorescence in situ hybridization.

2020年5月15日 · To discover how MCTs solve this fundamental aspect of intracellular monocarboxylate homeostasis in the context of multicellular organisms, we analyzed pyruvate transport activity of human monocarboxylate transporter 2 (MCT2). Here we show that MCT2 transport activity exhibits steep dependence on substrate concentration.

2023年4月18日 · 单羧酸转运蛋白 （MCT） 是蛋白质溶质载体家族 （SLC16） 的成员，由 14 种亚型组成。 MCT在许多不同的组织中表达，并参与基本细胞过程的调节（如糖酵解和脂肪酸稳态），也成为许多不同类型癌症的生物标志物。 在多项肿瘤研究中发现，MCT2活性增加可能对疾病的临床病程产生有利影响，但MCT2在体内肿瘤特性及肠道免疫中的作用尚不清楚。

2024年11月26日 · MCT1、MCT2、MCT3 和MCT4 负责一元羧酸在质膜上的双向质子连接转运，这些MCT 异构体显示出对短链单羧酸的偏好，包括在位置2 和3 上取代的单羧酸，例如丙酮酸、L-乳酸、D-β-羟基丁酸和乙酰乙酸，它们对不同底物有不同的亲和力（表1）。 与其他家族成员相比，MCT1 具有更广泛的分布和运输范围更广的底物。 MCT1 转运的研究最初集中在乳酸，在包括脂肪生成、糖异生和氧化磷酸化的代谢途径中，乳酸可用作从细胞外空间摄取的底物。 消耗 …