2024年12月25日 · MDC1 (Mediator Of DNA Damage Checkpoint 1) is a Protein Coding gene. Diseases associated with MDC1 include Glioma Susceptibility 1 and Aneurysm, Intracranial …

MDC1 protein is a regulator of the Intra-S phase and the G2/M cell cycle checkpoints and recruits repair proteins to the site of DNA damage. It is involved in determining cell survival fate in …

ATM激活后可以将MDC1（mediator of DNA damage checkpoint protein 1）磷酸化，再募集E3泛素连接酶RNF168，后者将组蛋白H2A泛素化，从而与53BP1（p53结合蛋白1）结合。 53BP1 …

2003年2月27日 · Here we identify a novel BRCA1 carboxy-terminal (BRCT) and forkhead-associated (FHA) domain-containing protein, MDC1 (mediator of DNA damage checkpoint …

Mediator of DNA Damage Checkpoint 1 (MDC1) Is a Novel Estrogen Receptor Coregulator in Invasive Lobular Carcinoma of the Breast. Impacts of lipid-related metabolites, adiposity, and …

DNA损伤修复相关基因(mediator of DNA damage check point protein 1，MDC1)又称BRCT结构域1的核因子(nuclear factor with BRCT domain protein 1，NFBD1)，是一种参与DNA损伤反应 …

2003年2月27日 · Here we identify a novel BRCA1 carboxy-terminal (BRCT) and forkhead-associated (FHA) domain-containing protein, MDC1 (mediator of DNA damage checkpoint …

This review will discuss reports that link MDC1 to cancer and identify MDC1 as an important player in tumor formation, progression, and treatment. We also discuss mechanisms by which …

由该基因编码的蛋白质包含一个 N 末端叉头结构域、两个 BRCA1 C 末端 (BRCT) 基序和一个具有 13 次重复的大约 41 个氨基酸序列的中心结构域。 编码的蛋白质需要激活 S 期内和 G2/M 期细 …

2005年9月25日 · Here we report that knockdown of MDC1 by RNA interference results in cellular hypersensitivity to the DNA cross-linking agent mitomycin C and ionizing radiation and in …