2024年12月25日 · MDC1 (Mediator Of DNA Damage Checkpoint 1) is a Protein Coding gene. Diseases associated with MDC1 include Glioma Susceptibility 1 and Aneurysm, Intracranial Berry, 4. Among its related pathways are HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) and Gene expression (Transcription).

MDC1 protein is a regulator of the Intra-S phase and the G2/M cell cycle checkpoints and recruits repair proteins to the site of DNA damage. It is involved in determining cell survival fate in association with tumor suppressor protein p53. This protein also goes by the name Nuclear Factor with BRCT Domain 1 (NFBD1).

ATM激活后可以将MDC1（mediator of DNA damage checkpoint protein 1）磷酸化，再募集E3泛素连接酶RNF168，后者将组蛋白H2A泛素化，从而与53BP1（p53结合蛋白1）结合。 53BP1可以促进NHEJ并抑制HR。

2003年2月27日 · Here we identify a novel BRCA1 carboxy-terminal (BRCT) and forkhead-associated (FHA) domain-containing protein, MDC1 (mediator of DNA damage checkpoint protein 1), which works with H2AX to...

Mediator of DNA Damage Checkpoint 1 (MDC1) Is a Novel Estrogen Receptor Coregulator in Invasive Lobular Carcinoma of the Breast. Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study. MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells.

DNA损伤修复相关基因(mediator of DNA damage check point protein 1，MDC1)又称BRCT结构域1的核因子(nuclear factor with BRCT domain protein 1，NFBD1)，是一种参与DNA损伤反应早期进程的支架蛋白，在调控DNA损伤应答和维持基因组稳定性方面发挥着重要功效。

2003年2月27日 · Here we identify a novel BRCA1 carboxy-terminal (BRCT) and forkhead-associated (FHA) domain-containing protein, MDC1 (mediator of DNA damage checkpoint protein 1), which works with H2AX to promote recruitment of repair proteins to the sites of DNA breaks and which, in addition, controls damage-induced cell-cycle arrest checkpoints.

This review will discuss reports that link MDC1 to cancer and identify MDC1 as an important player in tumor formation, progression, and treatment. We also discuss mechanisms by which MDC1 levels are regulated and how this contributes to tumor formation.

由该基因编码的蛋白质包含一个 N 末端叉头结构域、两个 BRCA1 C 末端 (BRCT) 基序和一个具有 13 次重复的大约 41 个氨基酸序列的中心结构域。 编码的蛋白质需要激活 S 期内和 G2/M 期细胞周期检查点以响应 DNA 损伤。 这种核蛋白与 DNA 双链位点附近的磷酸化组蛋白 H2AX 相互作用，突破其 BRCT 基序，并促进 ATM 激酶和减数分裂重组 11 蛋白复合物向 DNA 损伤灶的募集。 [RefSeq 提供，2008 年 7 月]

2005年9月25日 · Here we report that knockdown of MDC1 by RNA interference results in cellular hypersensitivity to the DNA cross-linking agent mitomycin C and ionizing radiation and in impaired homology-mediated...