2023年6月12日 · Accumulation of a-KG promoted oxidative stress in double-hit lymphoma (DHL), which depended on malate dehydrogenase 1 (MDH1)-mediated 2-hydroxyglutarate (2-HG) conversion. High levels of reactive...

2016年11月17日 · Protein arginine methyltransferase 4 (PRMT4/CARM1) methylates and inhibits MDH1 by disrupting its dimerization. Knockdown of MDH1 represses mitochondria respiration and inhibits glutamine metabolism, which sensitizes PDAC cells to oxidative stress and suppresses cell proliferation.

2017年3月6日 · We report the generation of malate through malate dehydrogenase 1 (MDH1) supports LDH to regenerate NAD during proliferation. MDH1 deletion in cancer cells slowed proliferation and glucose...

2021年5月19日 · We demonstrated that α-KG is promiscuously reduced to another metabolite, L-2HG, by the metabolic enzyme MDH1 in an acidic environment, which then increases ROS levels to induce the oxidation...

2025年3月25日 · Malate dehydrogenase 1 (MDH1) and isocitrate dehydrogenase 1 (IDH1) are two crucial enzymes in the process of energy metabolism. MDH1 plays a crucial role in the malate-aspartate shuttle in the cytoplasm by utilizing the coenzyme NAD/NADH to catalyze the interconversion of malate and oxaloacetate.

2023年6月12日 · Accumulation of a-KG promoted oxidative stress in double-hit lymphoma (DHL), which depended on malate dehydrogenase 1 (MDH1)-mediated 2-hydroxyglutarate (2-HG) conversion. High levels of reactive oxygen species (ROS) contributed to ferroptosis induction by promoting lipid peroxidation and TP53 activation.

2020年5月1日 · The new malate circulation model proposes that malate exported from the chloroplast is oxidized in the mitochondrion triggering ROS production, which can modulate growth and ultimately induce cell death.

P53 downregulates malate dehydrogenase 1 (MDH1) expression; however, MDH1 downregulates L-2HG expression, which inhibits a rise in reactive oxygen species (ROS) levels-as L-2HG is responsible for excessive ROS.

P53 下调苹果酸脱氢酶 1 (MDH1) 表达；然而，MDH1 下调 L-2-羟基戊二酸 (L-2HG) 表达，从而抑制活性氧 (ROS) 水平的升高，因为 L-2HG 是导致 ROS 过多的原因。 本研究揭示了高浓度AKG诱导食管鳞癌细胞细胞焦亡的驱动机制，并提出了HPV E6癌蛋白抑制细胞焦亡的分子途径。 Oncogene E6 plays a critical role in the development and progression of esophageal cancer caused by human papillomavirus (HPV) infection.

2016年11月17日 · Protein arginine methyltransferase 4 (PRMT4/CARM1) methylates and inhibits MDH1 by disrupting its dimerization. Knockdown of MDH1 represses mitochondria respiration and inhibits glutamine metabolism, which sensitizes PDAC cells to oxidative stress and suppresses cell proliferation.