
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 …
2014年7月29日 · In various breast cancer cell lines, we found that SIRT6 was phosphorylated at Ser(338) by the kinase AKT1, which induced the interaction and ubiquitination of SIRT6 by …
MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6 …
2021年3月16日 · Sirt6 controls the activity of MDM2, stimulating ROS production. Sirt6 also influences MDM2 to suppress Sirt1 activity, thereby also promoting cancer cell death.
Delivery of Long Non-coding RNA NEAT1 by Peripheral Blood ... - PubMed
2020年9月11日 · In lipopolysaccharide-induced FLSs, miR-23a inhibited the expression of MDM2, and overexpression of MDM2 partially rescued the inhibitory effect of miR-23a on FLS …
华裔牛人Science子刊探究癌症形成及耐药机制 - 生物通
2014年8月5日 · MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. Sirtuin 6 (SIRT6) is associated …
Mdm2-Mediated Degradation Of Sirt6 Phosphorylated By Akt1 …
Here, we show that AKT1 phosphorylates SIRT6 at Ser 338 and induces MDM2-SIRT6 interaction, priming SIRT6 for degradation via the MDM2-dependent ubiquitin-proteasome …
Sirt6 induced cell death, as widely reported, but Sirt1 contributed to cell death only when it was suppressed by Sirt6 via regulation of MDM2. Sirt6 and Sirt6-mediated suppression of Sirt1...
(PDF) MDM2-mediated degradation of SIRT6 phosphorylated by …
2014年12月1日 · Here, we show that AKT1 phosphorylates SIRT6 at Ser338 and induces MDM2-SIRT6 interaction, priming SIRT6 for degradation via the MDM2-dependent ubiquitin …
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 …
2014年7月29日 · In various breast cancer cell lines, we found that SIRT6 was phosphorylated at Ser 338 by the kinase AKT1, which induced the interaction and ubiquitination of SIRT6 by …
SIRT6, a Mammalian Deacylase with Multitasking Abilities
To target SIRT6 for proteasome-dependent degradation, the kinase AKT1 phosphorylates SIRT6 at Ser338 and induces the ubiquitination of SIRT6 by MDM2 . Overexpressing MDM2 …
MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6 …
The effects of Sirt6 and Sirt1 combine to regulate ROS-induced cancer cell death. Sirt6 controls the activity of MDM2, stimulating ROS production. Sirt6 also influences MDM2 to suppress …