2021年2月3日 · MDM2 and MDM4 work together and independently to inhibit and degrade the p53 tumor suppressor protein. MDM2 is known to monoubiquitinate the p53 protein; however, …

2020年5月19日 · The Mdm4 (alias MdmX) oncoprotein, like its paralogue and interaction partner Mdm2, antagonizes the tumor suppressor p53. p53-independent roles of the Mdm proteins are …

2025年3月30日 · This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53 …

We now know that MDM2 and MDM4 inhibit p53 in distinct and complementary ways: MDM4 regulates p53 activity, while MDM2 mainly regulates p53 stability. Upon DNA damage, MDM2 …

MDMX up-regulation contributes to p53 inactivation in tumors that retain wild-type p53. The reactivation of p53 by targeting MDMX or aspects of its production (e.g., mRNA splicing) is, …

2024年11月14日 · In this study, we found that overexpression of MDM4 in mutant p53 colon cancer cells was able to increase the expression level of GPX4, and knockdown of MDM4 was …

2025年3月11日 · Both Mdm2 and Mdm4 inhibit p53 activity by masking of its transcriptional activation domain. In addition, Mdm2 functions as an E3 ubiquitin ligase, targeting p53 for …

5 天之前 · MDM4 binds p53 to induce transcriptional inactivation and thus inhibits p53 function. Experimental evidence showed that p53 is kept inactive in the cytoplasm at high levels by …

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein …

Mdm4 is upregulated in a substantial proportion of stage I-IV human melanomas. It promotes the survival of metastatic melanoma by antagonizing p53. In xenografts, inhibition of the MDM4 …