10-Methacryloyloxydecyl dihydrogen phosphate (10-MDP, MDP Monomer) is a chemical compound used in dental adhesive materials. This organophosphate monomer was developed in 1981 by the Japanese company Kuraray for the preparation of dental adhesion polymers [1]

2024年11月1日 · 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) is one of the most studied functional monomers in dental materials, especially in adhesives. Through the methacrylic group it can copolymerize with other monomers and through the phosphoric group, it can ionically interact with dental hydroxyapatite (HAp) [1], [2], [3], [4].

The 10-MDP monomer has a long and hydrophobic spacer chain and creates a rich MDP-Ca salt adhesive interface, which improves adhesion strength, remaining stable after one year of water-storage [13,15,31,45,54].

2022年7月1日 · In a recent study, we found that treatment of acid-etched dentin with MDP alone resulted in inhibited MMP activity and reduced nanoleakage at the resin–dentin interface, suggesting that free MDP and/or MDP-Ca salts might inhibit the activity of proteases or improve the stability of collagen [23].

2025年1月1日 · The present study demonstrated that the toxicity of the widely used functional monomers 10-MDP and GPDM is concentration-dependent. Specifically, 10-MDP significantly reduced mitochondrial metabolism in hDPSCs to a greater extent compared to GPDM.

Dentin bonding is a key in restorative dentistry. Here, we developed a self-etching two-bottle adhesive system containing 10-methacryloyloxidecyl dihydrogen phosphate monomer (MDP) and the physical, mechanical, and biocompatible properties were evaluated. The characteristics of MDP were analyzed using nuclear magnetic resonance (NMR).

Bonding to different dental restorative materials is challenging. This study aimed to evaluate the effect of a 10-MDP-based dentin adhesive on the shear bond strength (SBS) of self-adhesive resin cement (RC) to implant abutment materials.

The collagen-protecting effects of MDP and its Ca salt were investigated using in-situ zymography, rhMMP-9 colorimetric assay, hydroxyproline assay, and molecular docking. Results: MDP forms a stable collagen-phosphate complex through hydrogen bonding with the collagen in dentin. Furthermore, it generates MDP-Ca salts that are deposited on the ...

The use of an MDP-containing adhesive and the shorter storage time were associated with higher bond strengths. At 48 hours, an overall incidence of 50.5% of Type 1 mode of failure (adhesive at ceramic/resin interface) occurred, as opposed to 68% after 6 months of water storage.

2025年1月7日 · The restorative dentist in these cases can use the 10-MDP monomer in self-etching systems to target non-demineralized dentin such as CLEARFIL™ Universal Bond Quick to establish an acid ... WW, Takamizawa T, Latta MA, Miyazaki M. Surface moisture influence on etch-and-rinse universal adhesive bonding. Am J Dent. 2019 Feb;32(1):33-38. ...