The phrase 'multidrug resistance mutation 1 (MDR1)' refers to a specific mutation that can occur at a gene known as the MDR1 gene, also known as the ABCB1 gene. Many herding breeds …

2024年12月24日 · ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, …

P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or …

MDR1 drug sensitivity occurs when dogs inherit a genetic variant in their ABCB1 gene (formerly known as the MDR1 gene). This variant causes a change in a protein called P-glycoprotein (P …

PDR 是指仅对诱导药物产生交叉耐药；而 MDR 是指肿瘤细胞对一种抗肿瘤药物产生抗药性的同时，对结构和作用机制不同的抗肿瘤药物产生交叉耐药性，又称多向性耐药（pleiotropic drug …

2022年8月30日 · Our study reveals a role for the drug efflux pump MDR1 in both acquired and intrinsic resistance to protein degraders in cancer cells and supports combination therapies …

The human multidrug resistance gene MDR1 encodes a membrane-bound transporter P-glycoprotein (Pgp) that confers the drug resistance of cancer cells by mediating an ATP …

2018年4月11日 · Ample evidence suggests that the expression of ATP-binding cassette (ABC) transporters, especially the multidrug resistance protein 1 (MDR1, also known as P …

MDR1 gene encodes for P glycoprotein (P-gp), which plays an important role in bioavailability and cell-toxicity limitation of a wide range of drugs and xenobiotics. Three single nucleotide …

2025年1月12日 · Explore the MDR1 transporter, its role in drug resistance, and how genetic variability affects its function and substrate specificity. The MDR1 transporter, also known as P …