Long-term depression at hippocampal mossy fiber-CA3 synapses …
2021年4月20日 · Our results show that neither acute nor chronic inhibition of p75NTR signaling impairs MF-LTD, while short-term plasticity, in particular paired-pulse facilitation, at MF-CA3 synapses is...
学术前沿！南方医科大学高天明课题组首次发现调节突触可塑性和 …
2021年10月20日 · 海马脑区的 长时程增强（ long-term potentiation ，LTP）是研究最多的一类突触可塑性，同时也被认为是学习记忆的一种细胞机制【1 】。 LTP根据其维持时间的长短可分为早期 LTP（E-LTP ）和晚期LTP（L-LTP ），E-LTP 由单次高频刺激（HFS ）诱导，维持时间约为1小时【2 】，L-LTP 由多次高频刺激诱导，维持时间超过1小时【3】。 尽管在过去的20 多年里，研究者们对LTP 的分子机制进行了大量研究，然而其细胞机制仍不清楚。 突触可塑性的表 …
程仅与突触后受体有关[7]．MFCA3突触的LTP为 非NMDA受体依赖型，脑片研究表明，该突触通路 的强直性LTP在其诱导和维持过程中双脉冲易化 （Pairedpulsefacilitation，PPF）效应会下降[8]．PPF
Presynaptic Ca2+ Entry Is Unchanged during Hippocampal Mossy …
2002年12月15日 · The hippocampal mossy fiber (MF)–CA3 synapse exhibits NMDA receptor-independent long-term potentiation (LTP), which is expressed by presynaptic mechanisms leading to persistent enhancement of transmitter release.
Multiple forms of LTP in hippocampal CA3 neurons use a …
We investigated long-term potentiation (LTP) at mossy fiber synapses on CA3 pyramidal neurons in the hippocampus. Using Ca 2+ imaging techniques, we show here that when postsynaptic Ca 2+ was...
Spike Train Timing-Dependent Associative Modification of …
2004年2月5日 · We here report that long-term potentiation (LTP) at the A/C synapses can be induced by association of brief spike trains in mossy fibers (MFs) from the dentate gyrus and A/C fibers.
Quantal mechanism of long-term potentiation in hippocampal …
1994年6月1日 · The quantal mechanism underlying the expression of long-term potentiation (LTP) was studied in the mossy-fiber (mf) synapses of the rat hippocampus. Whole-cell recordings were used to measure the excitatory postsynaptic currents (EPSCs) before and after LTP induction in brain slices maintained at 31 +/- 1 degrees C. 2.
Joint CP-AMPA and group I mGlu receptor activation is required …
2014年9月9日 · Repetitive activation of dentate gyrus PIIs by excitatory mossy fiber (MF) inputs induces Hebbian long-term potentiation (LTP). In contrast, long-term depression (LTD) emerges in the absence of PII activity.
Protein synthesis inhibition blocks the induction of mossy fiber …
2000年11月15日 · Protein synthesis inhibitors block mossy fiber(MF) LTP maintenance in vitro, but little is known about the effect of protein synthesis inhibitors on either induction or maintenance in MF-LTP in vivo. Here we study the role of protein synthesis in the induction of long-term potentiation at the mossy fiber-CA3 hippocampal synapse in vivo in ...
海马MF-CA3突触习得性LTP诱导后PPF效应的变化 - scnu.edu.cn
Abstract: The technique of paired-pulse test combined with electrophysiology and behavioral learning was used to examine the effect of behavioral long-term potentiation (LTP) on paired-pulse...
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