MF59 is an immunologic adjuvant that uses squalene.It is Novartis' proprietary adjuvant that is added to influenza vaccines to help stimulate the human body's immune response through production of CD4 memory cells. [1] [2] [3]MF59 is the first oil-in-water influenza vaccine adjuvant to be commercialized in combination with a seasonal influenza virus vaccine.

2024年12月20日 · MF59 is the adjuvant contained in Fluad quadrivalent (an influenza vaccine licensed and recommended for adults aged 65 or older). MF59 is an oil-in-water emulsion composed of squalene, which is a naturally occurring oil found in many plant and animal cells, as well as in humans. MF59, used in flu vaccines in Europe since 1997 and in the United ...

MF59® is an oil-in-water emulsion adjuvant and licensed for use in pandemic and seasonal influenza vaccines in many countries. MF59 is safe and well tolerated in humans. MF59-adjuvanted vaccination spares vaccine dose and enhances hemagglutination inhibiting antibodies against homologous and heterologous influenza virus strains.

MF59 Safety Profile. MF59 is a well-established, safe, and potent vaccine adjuvant that has been licensed in more than 30 countries, since its first approval in 1997. From the collective clinical trials and wide use during the 2009 pandemic, there is a large safety database available for the MF59 emulsion with the total number of administered doses reaching over ∼200 million. 28

MF59, an oil-in-water emulsion produced by microfluidization (MF), was the first adjuvant to be used in a licensed seasonal influenza vaccine [13, 69]. Squalene, the oil in MF59, is a naturally occurring hydrocarbon extracted from livers of the dog-shark, a small, non-endangered species. The preponderance of shark-derived squalene is used in ...

MF59 allows for broader cross-reactivity against viral strains not included in the vaccine. MF59 has been shown to be more potent for both antibody and T-cell responses than aluminum-based adjuvants. MF59 has broad potential to be used as a safe and effective vaccine adjuvant for a wide range of vaccine types.

2022年8月25日 · MF59 is an oil-in-water emulsion of squalene oil. Squalene, a naturally occurring substance found in humans, animals, and plants, is highly purified for the vaccine manufacturing process. Adding Adjuvants to Flu Vaccines. An adjuvant is an ingredient of some vaccines that helps promote a better immune response. Adjuvants also can reduce the ...

MF59 induced higher levels of production of IL-6, TNF-α, and RANTES in CD4KO mice than those in WT mice. Thus, MF59 in CD4KO mice may work in a mechanism different from the one in WT mice. Larger DC populations, including pDCs and CD11b hi/low DCs, NKT cells, and CD8 + T cells, were recruited in CD4KO mice than in WT mice after MF59 treatment.

2025年2月10日 · Currently, MF59 and MF59-like adjuvants have been successfully applied to various influenza vaccines and recombinant protein-based COVID-19 vaccines (Table 1) [5, 6].Among vaccines, seasonal influenza vaccine Fluad® is the first marketed MF59-adjuvanted vaccine and was approved for preventing influenza in people aged 65 and older in Italy in 1997.

The MF59 emulsion is immunostimulatory and the safety of each vaccine formulated with the adjuvant must be demonstrated under controlled clinical conditions. Chiron has tested MF59 under such controlled clinical conditions with an extensive set of well-characterized antigens in more than 18,000 subjects Table 4). These clinical cohorts have ...