2024年10月1日 · Here, we developed a transdermal platform integrating yeast-derived biomimetic glucan particles (GPs) and polymeric microneedles to overcome the hurdles and induce effective immunity. GPs served as carriers for encapsulating antigens in a pathogen-like manner.

2023年6月13日 · 有实验评估了MF59中每个单独成分（角鲨烯、表面活性剂Span 85和Tween 80或柠檬酸盐缓冲液）的效果。 发现任何一个单独的成分都不能发挥免疫刺激能力。 只有全配方的MF59乳液能诱导先天性和获得性免疫并刺激产生相应的细胞因子比如IL-8和趋化因子比如CCL-2和CCL-3。 当注射含有MF59佐剂的疫苗之后，MF59乳液在局部能够招募大量的免疫细胞到注射部位，并加强免疫细胞对抗原的吸收和呈递。 在注射之后的2-3周内可以观察到招募到注射部 …

MF59-adjuvanted vaccination spares vaccine dose and enhances hemagglutination inhibiting antibodies against homologous and heterologous influenza virus strains. The mechanisms of MF59 involve rapid induction of chemokines, inflammatory cytokines, recruiting multiple immune cells, uric acid and benign apoptosis of certain innate immune cells.

MF59-adjuvanted vaccination spares vaccine dose and enhances hemagglutination inhibiting antibodies against homologous and heterologous influenza virus strains. The mechanisms of MF59 involve rapid induction of chemokines, inflammatory cytokines, recruiting multiple immune cells, uric acid and benign apoptosis of certain innate immune cells.

MF59 is a potent oil-in-water emulsion used in influenza vaccines to enhance immune responses, especially in the elderly, by increasing the potency of antigens and broadening the immune response to different viral strains. AI generated definition based on: Micro and Nanotechnology in Vaccine Development, 2017

We previously demonstrated the safety and immunogenicity of an MF59-adjuvanted COVID-19 vaccine based on the SARS-CoV-2 spike glycoprotein stabilised in a pre-fusion conformation by a molecular clamp using HIV-1 glycoprotein 41 sequences. Here, we describe 12-month results in adults aged 18–55 years and ≥56 years.

Here we provide information on good manufacturing processes (GMP), and methods of characterization for postproduction release and demonstration of long-term stability of MF59, as well as representative data to demonstrate the consistency of the product.

2012年6月19日 · MF59 is a safe and well established vaccine adjuvant. The mechanism of action of adjuvants is often poorly defined. A key component of the mechanism of action of MF59 is cellular recruitment to the injection site. MF59 creates a local immunocompetent environment at the injection site.

2018年8月29日 · MF59-adjuvanted vaccination spares vaccine dose and enhances hemagglutination inhibiting antibodies against homologous and heterologous influenza virus strains. The mechanisms of MF59 involve rapid induction of chemokines, inflammatory cytokines, recruiting multiple immune cells, uric acid and benign apoptosis of certain innate immune cells.

Here we provide information on good manufacturing processes (GMP), and methods of charac-terization for postproduction release and demonstration of long-term stability of MF59, as well as representative data to demonstrate the consistency of the product.