2024年4月8日 · Loss of MEF2C lowered intracellular lipid content and uptake through decreased low-density lipoprotein receptor (LDLR) levels, and supplementation with oleic acid restored …

2024年7月3日 · The immunoblotting results of low-density lipoprotein cholesterol (LDL-c) uptake assay also demonstrated the excellent performance of B11-H2-Fc on recovering the LDL-c …

2020年6月12日 · Gong and colleagues found that the combination of rosuvastatin with GGPP most potently improved VSV-G lentivirus transduction via upregulating cell surface LDLR …

2020年6月1日 · Baseline LDLR expression assessed by flow cytometry at the surface of control lymphocytes was found at ΔMFI of 104 ± 16 AU and at ΔMFI of 19 ± 10 AU at the surface of …

2021年8月19日 · We demonstrate by using near-infrared fluorescence imaging the potential of this conjugate to specifically detect and discriminate primary PDAC from healthy organs …

2023年3月6日 · Increasing the availability of hepatic LDL receptors (LDLRs) remains a major clinical target for reducing LDL-C levels. Here, we describe a novel role for RNF130 (ring …

Cell-surface LDLR expression was assessed by flow cytometry with maximal median fluorescence intensity (MFI) levels of 5636 ± 605 in non-FH, 2297 ± 198 in HeFH (p < 0.01 vs. non-FH), 799 …

2020年7月9日 · Here, we show that DENV infection induces the expression of PCSK9, a negative regulator of the low-density lipoprotein receptor (LDLR). Increased PCSK9 levels in hypoxic …

Mechanistic studies reveal that EHBP1 promotes sortilin-mediated PCSK9 secretion, leading to LDL receptor (LDLR) degradation, decreased LDL uptake, and reduced TAZ, a fibrogenic …

Download scientific diagram | Mean fluorescence intensity (MFI) of LDL receptor expression in healthy subiects (bold line) and Down syndrome old subjects (fine line). from publication: LDL ...