2023年5月24日 · 研究发现， CD69 在维持Treg免疫抑制功能中起重要作用，Treg中敲低CD69容易诱发炎症性肠病等自身免疫性疾病。 此外， HSF1 通过激活CD69转录促进CD69+Tregs分化，这对Tregs的免疫抑制功能至关重要。 尤其是对于治疗自身免疫性疾病的患者来说，通过增加CD69+Treg的数量将有望缓解疾病症状，改善病情进展。 CD69作为淋巴细胞活化最早表达的分子，也就是当免疫系统激活时，CD69成为最早的信号，调节T细胞、B细胞、自然杀伤细胞等多 …

2021年4月7日 · 这些研究表明，cd69是t细胞活化后上调的 最早标志物之一，cd69表达的早期动力学和广泛分布使其成为在体外刺激试验中鉴定抗原反应性t细胞并有效纯化这些细胞的理想方法。但是，由于它会随细胞增殖而稀释，因此不能用于长期刺激试验。

2021年3月3日 · Inflammatory monocytes required the early activation marker CD69 to supply this S1P, in part because the expression of CD69 was associated with reduced levels of S1pr5 (which encodes S1P receptor...

2020年10月26日 · As predicted, promoter-deleted clones displayed lower basal CD69 levels (MFI = 117) and an inability to respond to stimulation (MFI = 125). Unexpectedly, the effects of the lack of the CNS2 regulatory region resembled those of promoter deficiency, in which CD69 expression was abolished both in the basal state (MFI = 114) and after PMA/IO ...

2023年7月6日 · Radiolabeled CD69 Ab PET/CT imaging (CD69 immuno-PET) was performed on GBM-bearing mice longitudinally to quantify CD69 and its association with survival following immunotherapy. We show CD69 expression is upregulated upon T-cell activation and on tumor-infiltrating lymphocytes (TIL) in response to immunotherapy.

Our findings identify CD69 and galectin-1 to be a novel regulatory receptor-ligand pair that modulates Th17 effector cell differentiation and function. CD69, a C-type lectin, is a member of the natural killer (NK) receptor family and is induced early following activation of leukocytes (1).

2024年6月1日 · In this study, we evaluated the contribution of CD69 and CD103 to the development and functionality of skin local memory involving T RM cells in a murine CHS model caused by 2,4-dinitrofluorobenzene (DNFB), where different degrees of T RM cell contribution can be observed in 1 mouse, using CD69KO (CD69-deficient mice) and CD103KO (CD103 ...

2020年6月15日 · cd69阳性组mfir高于cd69阴性组和正常对照组（p<0.01），后两者无显著性差异。 结论：cd69可以作为一个新的aml特异性抗原加入mrd检测方案中，并有望成为嵌合抗原受体修饰的t细胞（car-t）治疗aml的一个新靶点。

(C,D) Statistical comparison of CD69 expression in CD3 + cells, measured as median fluorescence intensity (MFI), between the four groups studied (C) and all groups vs. male CT (D). Median of...

MFI of CD69, CD11b, and CD16 in NK cells and CD54 and tmTNF in monocytes. Dots indicate LPS-or LPS + IFX (0.1, 0.3, 1, 3, and 10 mg)-treated samples means for each triplicate with SD. TNF is a...