2024年7月3日 · A labeled LDL complex (LDL-BODIPY) was used to assess the inhibitory effects of the Abs on PCSK9, and the mean fluorescence intensity (MFI) was measured as an indicator of LDL-c endocytosis.

2023年3月6日 · Removal of circulating plasma low-density lipoprotein cholesterol (LDL-C) by the liver relies on efficient endocytosis and intracellular vesicle trafficking. Increasing the availability of hepatic LDL receptors (LDLRs) remains a major clinical target for reducing LDL-C levels.

平均荧光强度(Mean Fluorescence Intensity, MFI)是描述偶联抗体的信号强弱的一种方法。 我们在阅读文献时，一般看到的MFI有两种：Mean Fluorescence Intensity或Median Fluorescence Intensity。 除了Mean和Media…

2011年4月15日 · Apolipoprotein B-100 (ApoB-100), the sole protein component of LDL, is known to bind to cell surface LDL receptor (LDLR) or cell surface-bound proteoglycans and to be internalized into cells. We found that APCs, consisting of macrophages and dendritic cells, upregulate LDLR on culture in vitro without obvious stimulation.

Mechanistic studies reveal that EHBP1 promotes sortilin-mediated PCSK9 secretion, leading to LDL receptor (LDLR) degradation, decreased LDL uptake, and reduced TAZ, a fibrogenic effector. At a cellular level, EHBP1 deficiency affects the intracellular localization of retromer, a protein complex required for sortilin stabilization.

2014年7月21日 · In the current study, we employed MG132 to evaluate the potential effects of proteasome inhibition on LDL-c clearance via detection of the LDLR expression and function in HepG2 cells. Our data...

2024年6月18日 · Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low-density lipoprotein receptor (LDLR) and mediates its internalization and degradation, resulting in an increase in LDL cholesterol levels. Recently, PCSK9 emerged as a therapeutic target for hypercholesterolemia and atherosclerosis.

2024年4月8日 · Loss of MEF2C lowered intracellular lipid content and uptake through decreased low-density lipoprotein receptor (LDLR) levels, and supplementation with oleic acid restored the cytotoxic function...

研究表明姜黄素可明显升高hepg2细胞ldlr的mrna及蛋白水平，通过激活srebp2并使得其靶基因ldlr表达水平增高 ，起到降脂的作用。

2025年3月2日 · 低密度脂蛋白受体（low density lipoprotein receptor, LDLR）参与胆固醇的代谢过程，在维持机体细胞胆固醇稳态中发挥着重要作用。 LDLR的表达受到转录、转录后及翻译后水平的精确调节，其表达失调将导致多种疾病的发生发展。