The Involvement of NR2B and tau Protein in MG132-Induced
2017年4月19日 · Tau siRNA induced reductive expression and dephosphoryaltion of Fyn, NR2B, and CREB, and MG132 treatment changes the interaction of Fyn and tau-5. a Screening of tau …
Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau …
2024年10月31日 · However, tau-WT clearance in the presence of methocarbamol + MG132 was significantly higher than that observed in the presence of MG132 alone, suggesting that …
Activation of transient receptor potential vanilloid 1 ameliorates tau ...
2023年8月29日 · Our findings reveal that capsaicin-induced TRPV1 activation confers neuroprotection by restoring neuronal tau homeostasis via modulating cellular autophagy and …
一种新型小分子PROTAC选择性地促进tau蛋白清除，以改善阿尔茨 …
2024年3月15日 · 此外，与蛋白酶体抑制剂MG132同时处理HEK293-hTau细胞，C004019诱导的tau清除被消除。 研究结论：C004019可以通过促进tau蛋白在体外泛素化及其随后在蛋白酶体 …
Tau protein binds to the P53 E3 ubiquitin ligase MDM2
2023年6月23日 · We show herein that Tau binds to MDM2 and that this inhibits P53 ubiquitination in vitro in a manner sensitive to the presence of the P301L mutation linked to FTLD-Tau. …
Activity-dependent tau cleavage by caspase-3 promotes neuronal ...
2023年6月16日 · MG132, a well characterized 26S subunit inhibitor, produced significantly more cleaved tau than other proteasome inhibitors, providing the most sensitive readout for cleaved …
Aggregate-selective removal of pathological tau by clustering
2024年8月29日 · To investigate whether degradation of aggregated tau in TVA cells by R-Nb F8-2 is reliant on these same mechanisms, we inhibited the E1 ubiquitin-activating enzyme with …
The Involvement of NR2B and tau Protein in MG132-Induced …
The current study demonstrated that MG132-inhibited proteasome activity resulted in a dose dependence of CREB dephosphorylation at Ser133 as well as decreased phosphorylation of N …
Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau …
2018年2月25日 · The application of Keap1 siRNA silencing and the proteasome inhibitor MG132 confirmed that peptide 1 could promote the Keap1-dependent poly-ubiquitination and …
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation
2017年1月1日 · We developed tau “seeding” assays in human cells and found that TRIM21 could intercept and potently neutralize antibody-labeled tau assemblies.